Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 10/20 | 0.44 |
| ▸ | PTPRC | P08575 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3264596 | 0.86 | PTPN1 (0.46) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4414758 | 0.79 | PTPN1 (0.70) | PTPN1PTPRCPTPN2 | |
| SCHEMBL4563377 | 0.77 | PTPN1 (0.41) | PTPN1PTPRC | |
| SCHEMBL4566574 | 0.74 | UGT2B7 (0.43) | PTPN1PTPRCPTPN2 | |
| SCHEMBL2311805 | 0.69 | KDM4E (0.54) | KDM4EALDH1A1ALOX5GAAMAPT | |
| SCHEMBL2312808 | 0.69 | KDM4E (0.54) | KDM4EALDH1A1ALOX5GAAMAPT | |
| SCHEMBL5610449 | 0.69 | KDM4E (0.58) | KDM4EALDH1A1ALOX5GAAMAPT | |
| SCHEMBL15095636 | 0.68 | PTPN1 (0.73) | PTPN1PTPRCPTPN2 | |
| SCHEMBL1639508 | 0.66 | KDM4E (0.47) | KDM4EALDH1A1ALOX5GAAMAPT | |
| SCHEMBL2298161 | 0.66 | MAPT (0.42) | KDM4EALDH1A1ALOX5GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2114971-A1 | FUSED AROMATIC PTP-1B INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2009-11-11 | — | — | EP | disclosed |
| WO-2008089581-A1 | FUSED AROMATIC PTP-1B INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2008-07-31 | — | — | WO | disclosed |