Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.34 |
| ▸ | PI4KA | P42356 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470022 | 0.71 | PI4KB (0.41) | HRH4LMNAALDH1A1PI4KBPI4KA | |
| SCHEMBL11954394 | 0.62 | KMT2A (0.51) | HRH4LMNAALDH1A1L3MBTL1CA12 | |
| SCHEMBL21633597 | 0.60 | HRH4 (0.54) | HRH4LMNAALDH1A1L3MBTL1IDO1 | |
| SCHEMBL15693585 | 0.60 | CA12 (0.59) | LMNAALDH1A1L3MBTL1CA12POLB | |
| SCHEMBL13866404 | 0.59 | LMNA (0.47) | HRH4LMNAALDH1A1L3MBTL1CA12 | |
| SCHEMBL12844810 | 0.57 | LMNA (0.45) | HRH4LMNAALDH1A1L3MBTL1CA12 | |
| SCHEMBL1831108 | 0.57 | MAPKAPK2 (0.41) | LMNAMAPK1 | |
| SCHEMBL12403764 | 0.56 | LMNA (0.44) | HRH4LMNAALDH1A1L3MBTL1CA12 | |
| SCHEMBL18233630 | 0.56 | LMNA (0.44) | HRH4LMNAALDH1A1L3MBTL1CA12 | |
| SCHEMBL854130 | 0.55 | L3MBTL1 (0.66) | ALDH1A1L3MBTL1ATMPOLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |