Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 6/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | KCNQ3 | O43525 | 6/20 | 0.32 |
| ▸ | KCNQ2 | O43526 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17425406 | 0.88 | IRAK4 (0.34) | CCNE1CDK2FLT3TYK2IRAK4 | |
| SCHEMBL455869 | 0.82 | TYK2 (0.41) | CCNE1CDK2FLT3TYK2IRAK4 | |
| SCHEMBL470189 | 0.75 | CCNE1 (0.42) | CCNE1CDK2FLT3TYK2IRAK4 | |
| SCHEMBL17416356 | 0.74 | TTK (0.59) | TTK | |
| SCHEMBL17425405 | 0.72 | JAK2 (0.32) | JAK2JAK3 | |
| SCHEMBL12986075 | 0.67 | L3MBTL1 (0.42) | HCRTR2 | |
| SCHEMBL458866 | 0.66 | SSTR4 (0.33) | HCRTR2 | |
| SCHEMBL3022172 | 0.66 | CCNE1 (0.43) | CCNE1CDK2FLT3TYK2IRAK4 | |
| SCHEMBL3022176 | 0.66 | CCNE1 (0.43) | CCNE1CDK2FLT3TYK2IRAK4 | |
| SCHEMBL140708 | 0.65 | TTK (0.37) | FLT3TYK2IRAK4TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |