Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 4/20 | 0.41 |
| ▸ | TTK | P33981 | 4/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.33 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.31 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17425401 | 0.88 | TYK2 (0.37) | TYK2TTKIRAK4 | |
| SCHEMBL456788 | 0.82 | CCNE1 (0.35) | TYK2TTKHCAR3MAPK14IRAK4 | |
| SCHEMBL17416356 | 0.78 | TTK (0.59) | TTK | |
| SCHEMBL470186 | 0.75 | TYK2 (0.45) | TYK2TTKCCNE1CDK2FLT3 | |
| SCHEMBL458281 | 0.75 | TYK2 (0.40) | TYK2TTKCCNE1CDK2FLT3 | |
| SCHEMBL17425406 | 0.71 | IRAK4 (0.34) | TYK2TTKIRAK4CCNE1CDK2 | |
| SCHEMBL458280 | 0.71 | TYK2 (0.43) | TYK2TTKCCNE1CDK2FLT3 | |
| SCHEMBL17425402 | 0.69 | TTK (0.56) | TTK | |
| SCHEMBL139927 | 0.69 | TTK (0.47) | TTKMAPK14 | |
| SCHEMBL12986323 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER IP GMBH (DE) | 2016-01-13 | — | — | EP | disclosed |
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |