Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.43 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.39 |
| ▸ | TUBB | P07437 | 5/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.39 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.39 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.39 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.39 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.39 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.39 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.39 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4568257 | 0.94 | IMPDH2 (0.45) | PDGFRBPDGFRAIMPDH2IMPDH1TUBB4A | |
| SCHEMBL4568266 | 0.85 | CDK5 (0.43) | PDGFRBPDGFRAIMPDH2IMPDH1KDM4E | |
| SCHEMBL6118162 | 0.85 | PDGFRB (0.42) | PDGFRBPDGFRAIMPDH2IMPDH1TUBB4A | |
| SCHEMBL4568293 | 0.85 | PDGFRB (0.42) | PDGFRBPDGFRAIMPDH2IMPDH1TUBB4A | |
| SCHEMBL4568258 | 0.82 | IMPDH2 (0.44) | PDGFRBPDGFRAIMPDH2IMPDH1TUBB4A | |
| SCHEMBL4568306 | 0.80 | CDK5 (0.38) | PDGFRBPDGFRAIMPDH2IMPDH1TUBB4A | |
| SCHEMBL4568272 | 0.80 | CCNB2 (0.39) | PDGFRBPDGFRAIMPDH2IMPDH1KDM4E | |
| SCHEMBL6118007 | 0.80 | RAB9A (0.59) | IMPDH2KDM4EMAPTRAB9AMEN1 | |
| SCHEMBL4568299 | 0.77 | CYP1A1 (0.42) | PDGFRBPDGFRAIMPDH2IMPDH1KDM4E | |
| SCHEMBL4568297 | 0.77 | NPY5R (0.40) | PDGFRBPDGFRAIMPDH2IMPDH1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680120-B2 | Indole derivative or pharmaceutically acceptable salt thereof | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2014-03-25 | — | — | US | disclosed |
| EP-2460791-A1 | INDOLE DERIVATIVE AND PHARMACOLOGICALLY ACCEPTABLE SALT THEREOF | Kissei Pharmaceutical Co., Ltd. (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20120129890-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-05-24 | — | — | US | disclosed |
| US-20120122931-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-20120122931-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | KISSEI PHARMACEUTICAL CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122931-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | PTGER1, CYSLTR1, LTB4R | PDGFRB 381/4885PDGFRA 884/4885IMPDH2 3385/4885 |
| US-20120129890-A1 | INDOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | PTGER1, CYSLTR1, ARRB1 | PDGFRB 310/4885PDGFRA 661/4885IMPDH2 3432/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.