SCHEMBL4568756

SCHEMBL4568756

CCCC(=O)c1cccc(OCC2CCCCC2)c1

nearest known ligand 0.51

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HPGD P15428 1/20 0.51
RAB9A P51151 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
KAT6A Q92794 1/20 0.50
ADAM17 P78536 1/20 0.49
PARP15 Q460N3 3/20 0.49
PARP10 Q53GL7 3/20 0.49
NR1H4 Q96RI1 1/20 0.48
SIRT2 Q8IXJ6 1/20 0.47
THRA P10827 1/20 0.47
THRB P10828 1/20 0.47
TLR4 O00206 1/20 0.46
TLR2 O60603 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4568749 1.00 HPGD (0.51) HPGDRAB9ASMN1; SMN2KAT6AADAM17
SCHEMBL4568983 0.99 NR1H4 (0.49) HPGDRAB9ASMN1; SMN2KAT6AADAM17
SCHEMBL22779392 0.93 NR1H4 (0.54) HPGDRAB9ASMN1; SMN2PARP15PARP10
SCHEMBL11993608 0.93 THRA (0.51) HPGDRAB9ASMN1; SMN2KAT6AADAM17
SCHEMBL23116621 0.90 HPGD (0.53) HPGDRAB9ASMN1; SMN2KAT6AADAM17
SCHEMBL2205674 0.88 KAT6A (0.53) KAT6APARP15PARP10NR1H4SIRT2
SCHEMBL29818710 0.88 KAT6A (0.53) KAT6APARP15PARP10NR1H4SIRT2
SCHEMBL2208791 0.88 KAT6A (0.53) KAT6APARP15PARP10NR1H4SIRT2
SCHEMBL13881738 0.87 PARP10 (0.52) KAT6APARP15PARP10NR1H4SIRT2
SCHEMBL2207833 0.86 THRA (0.59) HPGDRAB9ASMN1; SMN2KAT6AADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-20170049722-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2017-02-23 US disclosed
US-9458088-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2016-10-04 US disclosed
US-20150239836-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2015-08-27 US disclosed
US-20150239825-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2015-08-27 US disclosed
US-9079825-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-07-14 US disclosed
US-8993807-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-31 US disclosed
US-8981153-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2015-03-17 US disclosed
US-8829244-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2014-09-09 US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20150239836-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20150239825-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20170049722-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER HPGD 99/4885RAB9A 2120/4885SMN1; SMN2 42/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.