SCHEMBL4569040

SCHEMBL4569040

CC(C)(C)OC(=O)NCCC(=O)c1cccc(OCC2CCCCC2)c1

nearest known ligand 0.47

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
KAT6A Q92794 1/20 0.47
HPGD P15428 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
ADAM17 P78536 1/20 0.44
NR1H4 Q96RI1 1/20 0.43
SIRT2 Q8IXJ6 1/20 0.42
EPHX1 P07099 1/20 0.41
PARP15 Q460N3 1/20 0.40
PARP10 Q53GL7 1/20 0.40
ACACB O00763 2/20 0.40
ACACA Q13085 2/20 0.40
SLC2A1 P11166 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2205062 1.00 KAT6A (0.47) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL2202457 0.90 KAT6A (0.46) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL11996359 0.86 ACACB (0.52) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL25817595 0.84 HPGD (0.51) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL2206291 0.84 HPGD (0.51) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL17735445 0.83 KAT6A (0.48) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL19291614 0.82 NR1H4 (0.49) KAT6AHPGDRAB9ASMN1; SMN2ADAM17
SCHEMBL13323798 0.82 SMN1; SMN2 (0.43) SMN1; SMN2EPHX1ACACBACACA
SCHEMBL13400276 0.81 EPHX1 (0.41) RAB9ASMN1; SMN2EPHX1ACACBACACA
SCHEMBL13379595 0.81 ADAM17 (0.43) KAT6AHPGDRAB9ASMN1; SMN2ADAM17

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12029708-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2024-07-09 US disclosed
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2023-07-13 US disclosed
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2021-03-18 US disclosed
US-10639286-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2020-05-05 US disclosed
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2019-06-20 US disclosed
US-10188615-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2019-01-29 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. 2018-06-28 US disclosed
EP-3210966-A1 ALKOXYPHENYLPROPYLAMINES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION Acucela, Inc. (US) 2017-08-30 EP disclosed
US-9737496-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2017-08-22 US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 US disclosed
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA, INC. (US) 2013-08-01 US disclosed
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-08-23 US disclosed
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-24 US disclosed
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ACUCELA INC. (US) 2012-05-17 US disclosed
US-7982071-B2 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2011-07-19 US disclosed
US-20100113539-A1 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS ACUCELA, INC. (US) 2010-05-06 US disclosed
WO-2010048332-A2 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS ACUCELA, INC. (US) 2010-04-29 WO disclosed
US-20090326074-A1 Alkoxy compounds for disease treatment ACUCELA INC. (US) 2009-12-31 US disclosed
WO-2009045479-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ACUCELA INC. (US) 2009-04-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12029708-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20100113539-A1 COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS PDE6D, CLN6, ALDH1A2 KAT6A 2309/4885HPGD 119/4885RAB9A 783/4885
US-20120122938-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20210077427-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20230218549-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1794/4885HPGD 110/4885RAB9A 2078/4885
US-20190183816-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20130197096-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20120214852-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20090326074-A1 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-10188615-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20180177746-A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-20120129894-A1 Alkoxy Compounds for Disease Treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885
US-10639286-B2 Alkoxy compounds for disease treatment ALDH1A2, CLN6, AGER KAT6A 1820/4885HPGD 99/4885RAB9A 2120/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.