Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17007494 | 0.82 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL2477502 | 0.82 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL29793307 | 0.82 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL29561615 | 0.82 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL29506779 | 0.82 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL23790040 | 0.81 | HSP90AA1 (0.34) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL4569895 | 0.81 | HSP90AA1 (0.37) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL2371862 | 0.79 | HSP90AA1 (0.42) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL4569897 | 0.79 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 | |
| SCHEMBL17259197 | 0.79 | HSP90AA1 (0.36) | HSP90AA1HSP90AB1ALDH1A1SMN1; SMN2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120269864-A1 | Arginine Derivatives with NP-I Antagonistic Activity | GB06/019611.7 THERAPIES LIMITED (GB) | 2012-10-25 | — | — | US | disclosed |
| US-8227606-B2 | Arginine derivatives with NP-1 antagonistic activity | ARK THERAPEUTICS, LTD. (GB) | 2012-07-24 | — | — | US | disclosed |
| US-20120122862-A1 | ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY | GB06/019611.7 THERAPIES LIMITED (GB) | 2012-05-17 | — | — | US | disclosed |
| WO-2008040979-A1 | ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY | ARK THERAPEUTICS LTD. (GB) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120269864-A1 | Arginine Derivatives with NP-I Antagonistic Activity | NPFFR1, NPR1, ARG1 | HSP90AA1 3628/4885HSP90AB1 3444/4885ALDH1A1 2638/4885 |
| US-20120122862-A1 | ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY | NPFFR1, NPR1, ARG1 | HSP90AA1 3628/4885HSP90AB1 3444/4885ALDH1A1 2638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.