Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NRP1 | O14786 | 15/20 | 0.47 |
| ▸ | BRD4 | O60885 | 5/20 | 0.42 |
| ▸ | BRD2 | P25440 | 3/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13552650 | 0.87 | NRP1 (0.46) | NRP1 | |
| SCHEMBL4572267 | 0.82 | NRP1 (0.46) | NRP1 | |
| SCHEMBL4572340 | 0.80 | NRP1 (0.62) | NRP1 | |
| SCHEMBL4569880 | 0.80 | NRP1 (0.51) | NRP1 | |
| SCHEMBL4569901 | 0.80 | NRP1 (0.61) | NRP1 | |
| SCHEMBL4569878 | 0.77 | BRD4 (0.50) | BRD4BRD2BRD3 | |
| SCHEMBL4569884 | 0.76 | BRD4 (0.56) | BRD4BRD2BRD3 | |
| SCHEMBL4569890 | 0.76 | EDNRA (0.45) | BRD4BRD2BRD3 | |
| SCHEMBL4569881 | 0.75 | NRP1 (0.46) | NRP1 | |
| SCHEMBL1436327 | 0.71 | NRP1 (0.49) | NRP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8227606-B2 | Arginine derivatives with NP-1 antagonistic activity | ARK THERAPEUTICS, LTD. (GB) | 2012-07-24 | — | — | US | disclosed |
| US-20120122862-A1 | ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY | GB06/019611.7 THERAPIES LIMITED (GB) | 2012-05-17 | — | — | US | disclosed |
| US-8158789-B2 | Arginine derivatives with NP-I antagonistic activity | Ark Therapeutics Group Ltd. (GB) | 2012-04-17 | — | — | US | disclosed |
| US-20100022525-A1 | Arginine Derivatives with NP-I Antagonistic Activity | GB06/019611.7 THERAPIES LIMITED (GB) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122862-A1 | ARGININE DERIVATIVES WITH NP-I ANTAGONISTIC ACTIVITY | NPFFR1, NPR1, ARG1 | NRP1 145/4885BRD4 2083/4885BRD2 2089/4885 |
| US-20100022525-A1 | Arginine Derivatives with NP-I Antagonistic Activity | NPFFR1, NPR1, ARG1 | NRP1 145/4885BRD4 2083/4885BRD2 2089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.