Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3202804 | 0.89 | HRH4 (0.48) | HRH4CA12CA1CA2CA7 | |
| SCHEMBL3202812 | 0.89 | HRH4 (0.48) | HRH4CA12CA1CA2CA7 | |
| SCHEMBL3210544 | 0.79 | MAPK14 (0.65) | HRH4MAPK14GAAMGLLCCR5 | |
| Hydrochloric Acid SCHEMBL28743203 | 0.73 | MAPK14 (0.61) | MAPK14GAAMGLLCCR5 | |
| SCHEMBL2216397 | 0.72 | MAPK14 (0.64) | MAPK14GAAMGLLCCR5 | |
| SCHEMBL14185148 | 0.69 | ALDH1A1 (0.50) | GAASMN1; SMN2 | |
| SCHEMBL3882151 | 0.69 | HRH4 (0.56) | HRH4CA12CA1CA2CA7 | |
| SCHEMBL3193640 | 0.69 | ALDH1A1 (0.67) | HRH4CA12CA1CA2CA7 | |
| SCHEMBL3209676 | 0.67 | L3MBTL1 (0.50) | HRH4GAASMN1; SMN2ERN1 | |
| SCHEMBL3209679 | 0.67 | L3MBTL1 (0.50) | HRH4GAASMN1; SMN2ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2121602-A1 | 4-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL) INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2009-11-25 | — | — | EP | disclosed |
| WO-2008084491-A1 | 4-(HETEROCYCLYL)ALKYL-N-(ARYLSULFONYL) INDOLE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2008-07-17 | — | — | WO | disclosed |