Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.54 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31596990 | 0.97 | DRD2 (0.58) | DRD2TDP1CHRM2CHRM4CHRM5 | |
| SCHEMBL3524057 | 0.94 | DRD2 (0.66) | DRD2TDP1MAOAMAOBSIGMAR1 | |
| Iodide SCHEMBL15145961 | 0.92 | DRD2 (0.57) | DRD2TDP1CHRM2CHRM4CHRM5 | |
| SCHEMBL4743239 | 0.92 | ACHE (0.58) | DRD2TDP1CHRM2CHRM4CHRM5 | |
| SCHEMBL30572390 | 0.90 | DRD2 (0.57) | DRD2TDP1CHRM2CHRM4CHRM5 | |
| SCHEMBL29263630 | 0.90 | DRD2 (0.62) | DRD2TDP1MAOAMAOBSIGMAR1 | |
| SCHEMBL9127008 | 0.89 | DRD2 (0.60) | DRD2TDP1ACHEBACE1SIGMAR1 | |
| SCHEMBL8254760 | 0.87 | DRD2 (0.64) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL4024516 | 0.87 | DRD2 (0.56) | DRD2TDP1CHRM2CHRM4CHRM5 | |
| SCHEMBL24913972 | 0.87 | DRD2 (0.57) | DRD2TDP1MAOAMAOBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2142518-B1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | DONGWOO SYNTECH CO LTD (KR) | 2012-05-02 | — | — | EP | disclosed |
| US-8168646-B2 | 3,4-dihydroquinazoline derivatives | DONGWOO SYNTECH CO., LTD. (KR) | 2012-05-01 | — | — | US | disclosed |
| US-8168646-B2 | 3,4-dihydroquinazoline derivatives | DONGWOO SYNTECH CO., LTD. (KR) | 2012-05-01 | — | — | US | disclosed |
| US-20100120803-A1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | DONGWOO SYNTECH CO., LTD. (KR) | 2010-05-13 | — | — | US | disclosed |
| US-20100120803-A1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | DONGWOO SYNTECH CO., LTD. (KR) | 2010-05-13 | — | — | US | disclosed |
| WO-2008136631-A1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | DONGWOO SYNTECH CO., LTD. (KR) | 2008-11-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120803-A1 | 3,4-DIHYDROQUINAZOLINE DERIVATIVES | CACNA1I, CACNA1G, CACNA1H | DRD2 543/4885TDP1 2210/4885CHRM2 2244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.