Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.52 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.50 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.50 |
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573033 | 1.00 | GPR119 (0.54) | GPR119CHRM4NR1H2NR1H3ACACB | |
| SCHEMBL4573250 | 0.88 | CHRM4 (0.54) | CHRM4ACACBHDAC1FAAH | |
| SCHEMBL8110534 | 0.85 | CHRM4 (0.53) | GPR119CHRM4NR1H2NR1H3HDAC1 | |
| SCHEMBL31180987 | 0.84 | GPR119 (0.59) | GPR119NR1H2NR1H3ACACBHDAC1 | |
| SCHEMBL4573114 | 0.84 | GPR119 (0.51) | GPR119CHRM4NR1H2NR1H3HDAC1 | |
| SCHEMBL8116063 | 0.84 | GPR119 (0.51) | GPR119CHRM4NR1H2NR1H3HDAC1 | |
| SCHEMBL4585094 | 0.83 | GPR119 (0.50) | GPR119CHRM4NR1H2NR1H3SUV39H2 | |
| SCHEMBL4572976 | 0.82 | NR1H2 (0.49) | GPR119NR1H2NR1H3ACACBMAP4K4 | |
| SCHEMBL4572973 | 0.82 | NR1H2 (0.49) | GPR119NR1H2NR1H3ACACBMAP4K4 | |
| SCHEMBL21564435 | 0.81 | GPR119 (0.78) | GPR119HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |