Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.50 |
| ▸ | CCR1 | P32246 | 2/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | CTSB | P07858 | 1/20 | 0.43 |
| ▸ | CTSS | P25774 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573668 | 1.00 | SUV39H2 (0.50) | SUV39H2CCR1GPR119MAP4K4FAAH | |
| SCHEMBL8109925 | 0.90 | SUV39H2 (0.48) | SUV39H2CCR1GPR119MAP4K4FAAH | |
| SCHEMBL4573063 | 0.90 | SUV39H2 (0.48) | SUV39H2CCR1GPR119MAP4K4FAAH | |
| SCHEMBL4573153 | 0.90 | SUV39H2 (0.56) | SUV39H2CCR1GPR119MAP4K4FAAH | |
| SCHEMBL4573145 | 0.90 | SUV39H2 (0.56) | SUV39H2CCR1GPR119MAP4K4FAAH | |
| SCHEMBL4573197 | 0.87 | CTSB (0.46) | SUV39H2CCR1FAAHCTSBCTSS | |
| SCHEMBL4585094 | 0.86 | GPR119 (0.50) | SUV39H2GPR119NR1H2NR1H3CHRM4 | |
| SCHEMBL4573160 | 0.85 | SUV39H2 (0.47) | SUV39H2GPR119MAP4K4NR1H2NR1H3 | |
| SCHEMBL8117347 | 0.85 | SUV39H2 (0.47) | SUV39H2GPR119MAP4K4NR1H2NR1H3 | |
| SCHEMBL21659668 | 0.85 | GPR119 (0.49) | SUV39H2GPR119MAP4K4FAAHNR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |