SCHEMBL4573197 — predicted protein targets

Predicted protein targets (top 16)

	gene	UniProt	supporting neighbours	confidence
▸	CTSB	P07858	2/20	0.46

▸	CTSS	P25774	2/20	0.46

▸	CTSK	P43235	2/20	0.46

▸	CHRM4	P08173	4/20	0.43

▸	CCR1	P32246	2/20	0.43

▸	SUV39H2	Q9H5I1	2/20	0.42

▸	FAAH	O00519	4/20	0.42

▸	KDM4E	B2RXH2	3/20	0.41

▸	KMT2A	Q03164	2/20	0.39

▸	NPC1	O15118	1/20	0.39

▸	RAB9A	P51151	1/20	0.39

▸	MEN1	O00255	1/20	0.39

▸	ALDH1A1	P00352	1/20	0.39

▸	LMNA	P02545	1/20	0.39

▸	GAA	P10253	1/20	0.39

▸	TRPC6	Q9Y210	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4574549	0.89	SUV39H2 (0.40)	CTSBCTSSCTSKCHRM4CCR1
SCHEMBL4585200	0.89	CTSB (0.54)	CTSBCTSSCTSKCHRM4CCR1
SCHEMBL4573141	0.87	SUV39H2 (0.50)	CTSBCTSSCTSKCHRM4CCR1
SCHEMBL4573668	0.87	SUV39H2 (0.50)	CTSBCTSSCTSKCHRM4CCR1
SCHEMBL23855515	0.83	ACACB (0.48)	FAAHKMT2ANPC1RAB9AGAA
SCHEMBL23855514	0.83	ACACB (0.48)	FAAHKMT2ANPC1RAB9AGAA
SCHEMBL23855529	0.83	ACACB (0.48)	FAAHKMT2ANPC1RAB9AGAA
SCHEMBL4573183	0.82	CCR1 (0.46)	CTSBCTSSCTSKCHRM4CCR1
SCHEMBL4573207	0.80	SUV39H2 (0.45)	CTSBCTSSCTSKCHRM4CCR1
SCHEMBL4573031	0.80	FAAH (0.46)	CTSBCTSSCTSKCHRM4CCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2009001127-A1	CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS	ASTRAZENECA AB (SE)	2008-12-31	—	—	WO	disclosed