Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.42 |
| ▸ | CPS1 | P31327 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108230 | 1.00 | SUV39H2 (0.48) | SUV39H2MAP4K4GPR119FAAHSTS | |
| SCHEMBL28094394 | 0.88 | MAP4K4 (0.49) | SUV39H2MAP4K4GPR119HDAC1MAPT | |
| SCHEMBL4573168 | 0.85 | SLC6A9 (0.46) | FAAHMAPTROCK2PRKG1CPS1 | |
| SCHEMBL21280226 | 0.84 | MAPT (0.58) | SUV39H2MAP4K4GPR119MAPTALDH1A1 | |
| SCHEMBL4573145 | 0.80 | SUV39H2 (0.56) | SUV39H2MAP4K4GPR119FAAH | |
| SCHEMBL4573153 | 0.80 | SUV39H2 (0.56) | SUV39H2MAP4K4GPR119FAAH | |
| SCHEMBL4573445 | 0.79 | MAP4K4 (0.54) | SUV39H2MAP4K4GPR119FAAHHDAC1 | |
| SCHEMBL1904867 | 0.78 | SUV39H2 (0.48) | SUV39H2MAP4K4GPR119HDAC1MAPT | |
| SCHEMBL1062063 | 0.78 | GALR2 (0.51) | SUV39H2GPR119STSMAPTALDH1A1 | |
| SCHEMBL1900868 | 0.78 | SUV39H2 (0.48) | SUV39H2MAP4K4GPR119HDAC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |