Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.45 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.45 |
| ▸ | CPS1 | P31327 | 3/20 | 0.45 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573259 | 0.85 | SUV39H2 (0.48) | SLC6A9ROCK2PRKG1CPS1FAAH | |
| SCHEMBL8108230 | 0.85 | SUV39H2 (0.48) | SLC6A9ROCK2PRKG1CPS1FAAH | |
| SCHEMBL4585200 | 0.77 | CTSB (0.54) | FAAH | |
| SCHEMBL4573061 | 0.77 | ROCK2 (0.48) | ROCK2PRKG1CPS1FAAHCYP1A2 | |
| SCHEMBL22445489 | 0.75 | NCF1 (0.55) | ROCK2PRKG1KDM4EMAPTPDGFRB | |
| SCHEMBL19049589 | 0.73 | NOTUM (0.50) | KDM4ECYP1A2MAPTTSHR | |
| SCHEMBL4573183 | 0.73 | CCR1 (0.46) | FAAH | |
| SCHEMBL4573207 | 0.73 | SUV39H2 (0.45) | CPS1FAAH | |
| SCHEMBL19096995 | 0.72 | CTSB (0.46) | FAAHMAPT | |
| SCHEMBL19096994 | 0.72 | CTSB (0.46) | FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |