Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 5/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.47 |
| ▸ | HTR3B | O95264 | 2/20 | 0.47 |
| ▸ | HTR3A | P46098 | 2/20 | 0.47 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.47 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16001200 | 0.85 | ADRB1 (0.53) | HTR1AHTR7CHRNB2CHRNA4ADRB1 | |
| SCHEMBL8114648 | 0.84 | CHEK1 (0.47) | HTR1AHTR7ALKCHEK1 | |
| SCHEMBL4573103 | 0.82 | ADRB1 (0.58) | HTR1AHTR7ADRB1HTR3EHTR3B | |
| SCHEMBL4573471 | 0.81 | ADRB1 (0.56) | HTR1AHTR7CHRNB2CHRNA4ADRB1 | |
| SCHEMBL24989042 | 0.78 | ADRB1 (0.51) | HTR1AHTR7CHRNB2CHRNA4ADRB1 | |
| SCHEMBL4573825 | 0.77 | ACVR1 (0.51) | HTR1AHTR7ADRB1HTR3EHTR3B | |
| SCHEMBL361649 | 0.77 | ADRB1 (0.61) | HTR1AHTR7CHRNB2CHRNA4ADRB1 | |
| SCHEMBL22601531 | 0.76 | ADRB1 (0.53) | HTR1AHTR7CHRNB2CHRNA4ADRB1 | |
| Hydrochloric Acid SCHEMBL7711565 | 0.75 | ADRB1 (0.59) | HTR1AHTR7CHRNB2CHRNA4ADRB1 | |
| Hydrochloric Acid SCHEMBL2156292 | 0.75 | ADRB1 (0.59) | HTR1AHTR7CHRNB2CHRNA4ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |