Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | CPS1 | P31327 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14660395 | 0.85 | LMNA (0.46) | SMN1; SMN2LMNAPOLBGBA2SMYD3 | |
| SCHEMBL27544893 | 0.84 | LMNA (0.44) | SMN1; SMN2LMNAPOLBGBA2SMYD3 | |
| SCHEMBL6906792 | 0.81 | PDK1 (0.48) | SMN1; SMN2LMNAPOLBGBA2SMYD3 | |
| SCHEMBL30287911 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAPOLBALDH1A1NPC1 | |
| SCHEMBL7788793 | 0.80 | GBA2 (0.51) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL11399215 | 0.78 | SMYD3 (0.43) | SMN1; SMN2LMNAPOLBGBA2SMYD3 | |
| SCHEMBL22578805 | 0.76 | POLB (0.46) | SMN1; SMN2LMNAPOLBGBA2SMYD3 | |
| SCHEMBL20589075 | 0.75 | POLB (0.49) | SMN1; SMN2LMNAPOLBGBA2ALDH1A1 | |
| SCHEMBL6181767 | 0.75 | SETD7 (0.47) | SMN1; SMN2PDK1PDK2PDK3PDK4 | |
| SCHEMBL29701090 | 0.74 | LMNA (0.44) | SMN1; SMN2LMNAPOLBGBA2SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |