Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.39 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14660395 | 0.84 | LMNA (0.46) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL27544893 | 0.83 | LMNA (0.44) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL4573340 | 0.81 | SMN1; SMN2 (0.43) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL7788793 | 0.79 | GBA2 (0.51) | LMNAPOLBSMN1; SMN2GBA2 | |
| SCHEMBL3393183 | 0.77 | PDK1 (0.43) | PDK1PDK2PDK3PDK4LMNA | |
| SCHEMBL3395559 | 0.77 | SETD7 (0.47) | PDK1PDK2PDK3PDK4SMN1; SMN2 | |
| SCHEMBL22578805 | 0.75 | POLB (0.46) | LMNAPOLBSMN1; SMN2GBA2SMYD3 | |
| SCHEMBL3311629 | 0.75 | LMNA (0.51) | LMNAPOLBSMN1; SMN2P2RY12 | |
| SCHEMBL20589075 | 0.74 | POLB (0.49) | LMNAPOLBSMN1; SMN2GBA2MAPT | |
| SCHEMBL29701090 | 0.73 | LMNA (0.44) | LMNAPOLBSMN1; SMN2GBA2SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1490346-A2 | STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINES | SCHERING CORPORATION (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003084942-A2 | STEREOSELECTIVE ALKYLATION OF CHIRAL 2-METHYL-4-PROTECTED PIPERAZINES | SCHERING CORPORATION (US) | 2003-10-16 | — | — | WO | disclosed |