Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | TSHR | P16473 | 2/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | GLA | P06280 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2213963 | 0.84 | NPSR1 (0.70) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL5922348 | 0.82 | LMNA (0.69) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL14276075 | 0.80 | ALDH1A1 (0.63) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL7168904 | 0.79 | CHRNA7 (0.60) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL4574483 | 0.78 | ALDH1A1 (0.49) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL1156108 | 0.78 | ALDH1A1 (0.64) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL7166012 | 0.77 | LMNA (0.66) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL31650801 | 0.77 | ALDH1A1 (0.60) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL7165586 | 0.77 | TP53 (0.74) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 | |
| SCHEMBL5922342 | 0.77 | CHRNA7 (0.72) | ALDH1A1HPGDTSHRSMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319084-B2 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-01-15 | — | — | US | disclosed |
| US-20060178490-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E. I. DU PONT DE NEMOURS AND COMPANY | 2006-08-10 | — | — | US | disclosed |
| US-20050054856-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | EASTMAN CHEMICAL COMPANY (US) | 2005-03-10 | — | — | US | disclosed |
| US-6825356-B2 | REMAINING DONOR ATOMS OF THE LIGAND ARE SELECTED FROM THE GROUP CONSISTING OF C, N, P, AS, O, S, AND SE | EASTMAN CHEMICAL COMPANY | 2004-11-30 | — | — | US | disclosed |
| US-20030225228-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | EASTMAN CHEMICAL COMPANY | 2003-12-04 | — | — | US | disclosed |
| US-20030195110-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | E. I. DU PONT DE NEMOURS AND COMPANY | 2003-10-16 | — | — | US | disclosed |
| US-6559091-B1 | Metal complex ligated by a monodentate, bidentate, tridentate, or tetradentate ligand, wherein at least one of the donor atoms of the ligand is a nitrogen atom substituted by a 1-pyrrolyl or substituted 1- pyrrolyl group | EASTMAN CHEMICAL COMPANY | 2003-05-06 | — | — | US | disclosed |
| US-6545108-B1 | Ti, Zr, Hf, Cr, Mo, W, V, Nb, or Ta complex of a monodentate dianionic ligand in which a nitrogen atom is substituted by a 1-pyrrolyl and the remaining donor atoms are N, P, As, O, S, or Se | EASTMAN CHEMICAL COMPANY | 2003-04-08 | — | — | US | disclosed |
| EP-1278784-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2003-01-29 | — | — | EP | disclosed |
| EP-1192189-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2001083571-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2001-11-08 | — | — | WO | disclosed |
| WO-2000050470-A2 | CATALYSTS CONTAINING N-PYRROLYL SUBSTITUTED NITROGEN DONORS | EASTMAN CHEMICAL COMPANY (US) | 2000-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060178490-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | NCL, NSFL1C, NCLN | ALDH1A1 3786/4885HPGD 79/4885TSHR 4856/4885 |
| US-20050054856-A1 | Catalysts containing N-pyrrolyl substituted nitrogen donors | NCL, NSFL1C, NCLN | ALDH1A1 3786/4885HPGD 79/4885TSHR 4856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.