Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16081232 | 0.86 | SSTR4 (0.48) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL1488276 | 0.84 | L3MBTL1 (0.56) | MEN1KMT2APOLBL3MBTL1DRD3 | |
| SCHEMBL16081239 | 0.84 | SIGMAR1 (0.45) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL16081233 | 0.84 | SIGMAR1 (0.45) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL10976738 | 0.83 | MEN1 (0.56) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL16081245 | 0.81 | SIGMAR1 (0.43) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL16081243 | 0.81 | SIGMAR1 (0.43) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL16081231 | 0.80 | SSTR4 (0.44) | MEN1KMT2AKDM4EUSP2POLB | |
| SCHEMBL16081227 | 0.79 | PLA2G2A (0.48) | MEN1KMT2APOLBACHEL3MBTL1 | |
| SCHEMBL16085590 | 0.78 | KMT2A (0.49) | MEN1KMT2AACHEL3MBTL1DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008047883-A1 | PIPERAZINE-SUBSTITUTED BENZOTHIOPHENES FOR TREATMENT OF MENTAL DISORDERS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-04-24 | — | — | WO | disclosed |