Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | DNM1 | Q05193 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4280071 | 0.82 | ALDH1A1 (0.70) | ALDH1A1DNM1SMN1; SMN2SIGMAR1TDP1 | |
| SCHEMBL4327257 | 0.74 | ACKR3 (0.44) | ALDH1A1 | |
| SCHEMBL31622466 | 0.74 | DNM1 (0.42) | ALDH1A1DNM1SMN1; SMN2SIGMAR1TDP1 | |
| SCHEMBL22954469 | 0.74 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2SIGMAR1TDP1LMNA | |
| SCHEMBL9272604 | 0.73 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2SIGMAR1TDP1LMNA | |
| SCHEMBL13661121 | 0.73 | ALDH1A1 (0.66) | ALDH1A1DNM1SMN1; SMN2SIGMAR1TDP1 | |
| SCHEMBL27331646 | 0.71 | ALDH1A1 (0.39) | ALDH1A1SMN1; SMN2SIGMAR1TDP1 | |
| SCHEMBL2935834 | 0.71 | ALDH1A1 (0.64) | ALDH1A1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL21066379 | 0.71 | KMT2A (0.41) | ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL31297447 | 0.71 | ALDH1A1 (0.38) | ALDH1A1DNM1SMN1; SMN2SIGMAR1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008107322-A1 | INDOLE, BENZIMIDAZOLE OR BENZOTRIAZOLE DERIVATIVES INCLUDING A PIPERIDINE OR PIPERAZINE CORE AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |
| WO-2008107321-A1 | HETEROCYCLIC COMPOUNDS USED AS ANTI-NEOPLASIC AGENTS OR CELL PROLIFERATION INHIBITORS | CEREP (FR) | 2008-09-12 | — | — | WO | disclosed |