Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422251 | 0.85 | MEN1 (0.68) | SMN1; SMN2HTTALDH1A1MAPK10L3MBTL1 | |
| SCHEMBL31240707 | 0.84 | CYP1A2 (0.58) | SMN1; SMN2HTTCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4574655 | 0.79 | CYP1A2 (0.66) | SMN1; SMN2HTTCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL4575173 | 0.78 | MAPT (0.61) | SMN1; SMN2HTTCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL7505406 | 0.77 | HTR1A (0.67) | SMN1; SMN2HTTCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL26238933 | 0.76 | MEN1 (0.49) | CYP1A2CYP2C9CYP2C19ALDH1A1KDM4E | |
| SCHEMBL2130310 | 0.75 | NOS2 (0.53) | SMN1; SMN2CYP3A4CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL19611852 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2HTTCYP3A4CYP1A2CYP2D6 | |
| SCHEMBL11961829 | 0.73 | NOS2 (0.57) | SMN1; SMN2CYP1A2CYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL8277611 | 0.73 | SMN1; SMN2 (0.51) | SMN1; SMN2HTTCYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319104-B2 | hPPARs activators | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-15 | — | — | US | disclosed |
| US-20050137212-A1 | Hppars activators | SMITHKLINE BEECHAM CORPORATION | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137212-A1 | Hppars activators | PPARG, PPARA, PPARD | SMN1; SMN2 3258/4885HTT 798/4885CYP3A4 372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.