Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | ME2 | P23368 | 6/20 | 0.49 |
| ▸ | ME1 | P48163 | 6/20 | 0.49 |
| ▸ | ME3 | Q16798 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1712413 | 0.83 | CHKA (0.51) | DRD4DRD2DRD3GAAMAPT | |
| SCHEMBL1018073 | 0.82 | MAPT (0.61) | GAAMAPTKDM4ELMNAALDH1A1 | |
| SCHEMBL1412431 | 0.81 | CHRNA7 (0.58) | DRD4DRD2DRD3MAPTKDM4E | |
| SCHEMBL17923026 | 0.81 | ALDH1A1 (0.46) | DRD4GAAMAPTKDM4EALDH1A1 | |
| SCHEMBL23355697 | 0.80 | S1PR1 (0.44) | DRD4DRD2DRD3MAPTLMNA | |
| SCHEMBL23780016 | 0.79 | MAPT (0.41) | DRD4DRD2DRD3GAAMAPT | |
| SCHEMBL6032280 | 0.79 | CHKA (0.52) | DRD4POLB | |
| SCHEMBL27605992 | 0.79 | CHRNA7 (0.38) | DRD4DRD2DRD3GAAMAPT | |
| SCHEMBL7041242 | 0.78 | MAPT (0.68) | DRD4DRD2DRD3ME2ME1 | |
| SCHEMBL3632512 | 0.77 | CTSK (0.60) | MAPTLMNAALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014047427-A2 | SUBSTITUTED BENZOFURAN, BENZOTHIOPHENE AND INDOLE MCL-1 INHIBITORS | VANDERBILT UNIVERSITY (US) | 2014-03-27 | — | — | WO | disclosed |
| WO-2008055959-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS N.V. (BE) | 2008-05-15 | — | — | WO | disclosed |