Leucovorin

Leucovorin

SCHEMBL4575698

Nc1nc2c(c(=O)[nH]1)N(C=O)C(CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1)CN2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 1.00
LMNA P02545 1/20 0.79
MTHFD1 P11586 2/20 0.71
SOST Q9BQB4 1/20 0.67
MTHFD2 P13995 2/20 0.62
FPGS Q05932 2/20 0.60
TYMS P04818 1/20 0.55
GART P22102 5/20 0.55
ATIC P31939 3/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Leucovorin SCHEMBL159828 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Leucovorin SCHEMBL258832 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Levoleucovorin SCHEMBL639769 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Leucovorin SCHEMBL3031362 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Folinic Acid SCHEMBL29616563 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Leucovorin SCHEMBL29385578 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Leucovorin SCHEMBL29379632 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Leucovorin SCHEMBL36113 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Folinic Acid SCHEMBL21498299 1.00 DHFR (1.00) DHFRLMNAMTHFD1SOSTMTHFD2
Leucovorin SCHEMBL4744838 0.99 DHFR (0.98) DHFRLMNAMTHFD1SOSTMTHFD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 366 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3841097-B1 2,6-BIS(((1H-BENZO[D]IMIDAZOL-2-YL)THIO)METHYL)PYRIDINE AND N2,N6-DIBENZYLPYRIDINE-2,6-DICARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE (PI3K) INHIBITORS FOR TREATING CANCER BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS BRFAA (GR) 2026-05-20 EP claimed
CN-122005500-A Platinum folinate protein nanoparticle and preparation method and application thereof 苏州大学 2026-05-12 CN claimed
EP-3645742-B1 ANTI-ROR1 ANTIBODIES AND METHODS OF MAKING AND USING THEREOF SYSTIMMUNE INC (US) 2026-04-29 EP claimed
EP-3781713-B1 SYSTEMS AND METHODS FOR DETECTING CANCER VIA CFDNA SCREENING MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2026-03-18 EP claimed
EP-4034169-B1 THERAPEUTIC DENDRIMER STARPHARMA PTY LTD (AU) 2026-02-11 EP claimed
EP-3679924-B1 FORMULATION COMPRISING PARTICLES WOERWAG PHARMA GMBH & CO KG (DE) 2025-12-17 EP claimed
EP-3212228-B1 MARAVIROC ALONE OR IN COMBINATION THERAPY FOR THE TREATMENT OF CANCER UNIV HEIDELBERG RUPRECHT KARLS (DE) 2025-12-03 EP claimed
EP-3806898-B1 GREMLIN-1 ANTAGONIST FOR USE IN THE TREATMENT OF CANCER UCB Biopharma SRL (BE) 2025-10-08 EP claimed
EP-3965808-B1 USE OF PARASITES AND EXTRACELLULAR VESICLES OBTAINED FROM PARASITES IN CANCER TREATMENT UNIV YEDITEPE (TR) 2025-09-03 EP claimed
EP-3719018-B1 PURINE AND DEAZAPURINE DERIVATIVES AS PHARMACEUTICAL COMPOUNDS ASTEX THERAPEUTICS LTD (GB) 2025-08-27 EP claimed
EP-3463345-B1 PHARMACEUTICAL COMBINATIONS ARRAY BIOPHARMA INC (US) 2022-11-02 EP claimed
EP-3337456-B1 LIPOSOMES WITH GINSENOSIDE AS MEMBRANE MATERIAL AND PREPARATIONS AND USE THEREOF SHANGHAI GINPOSOME PHARMATECH CO LTD (CN) 2022-10-26 EP claimed
EP-2958945-B1 COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER ASTELLAS PHARMA INC (JP) 2022-10-19 EP claimed
CN-112691107-B Pharmaceutical composition and application thereof 北京斯利安药业有限公司 2022-09-02 CN claimed
EP-3725810-B1 COMBINATION THERAPY INVOLVING ANTIBODIES AGAINST CLAUDIN 18.2 FOR TREATMENT OF CANCER ASTELLAS PHARMA INC (JP) 2022-07-06 EP claimed
EP-2773355-B1 METHODS, FORMULATIONS, AND KITS FOR RAPIDLY REPLETING FOLATE LEVELS IN WOMEN SOUTH ALABAMA MEDICAL SCIENCE FOUND (US) 2022-06-08 EP claimed
EP-3319965-B1 NOVEL COMPOUNDS FOR USE IN TREATING OR PREVENTING CANCEROUS DISEASES BIOMEDICAL RES FOUNDATION OF THE ACADEMY OF ATHENS (GR) 2022-05-04 EP claimed
EP-3218007-B1 METHODS AND PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF CANCER INST NAT SANTE RECH MED (FR) 2022-04-06 EP claimed
CN-113993890-A anti-CD 73, anti-PD-L1 antibodies and chemotherapy for the treatment of tumors 免疫医疗有限责任公司 2022-01-28 CN claimed
EP-3778868-B1 CELL CULTURE MEDIUM FOR CULTIVATING CELLS, METHOD FOR CULTURING CELLS AND METHOD FOR EXPRESSING AT LEAST ONE RECOMBINANT PROTEIN IN A CELL CULTURE UGA BIOPHARMA GMBH (DE) 2022-01-26 EP claimed