Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Leucovorin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR known ✓ | P00374 | 1/20 | 0.98 |
| ▸ | TYMS known ✓ | P04818 | 1/20 | 0.55 |
| ▸ | GART known ✓ | P22102 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | MTHFD1 | P11586 | 2/20 | 0.70 |
| ▸ | SOST | Q9BQB4 | 1/20 | 0.66 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.61 |
| ▸ | FPGS | Q05932 | 2/20 | 0.59 |
| ▸ | ATIC | P31939 | 3/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Levoleucovorin SCHEMBL639769 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Folinic Acid SCHEMBL29616563 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL258832 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL29379632 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL3031362 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL36113 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL4575698 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL29385578 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Folinic Acid SCHEMBL21498299 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 | |
| Leucovorin SCHEMBL159828 | 0.99 | DHFR (1.00) | DHFRLMNAMTHFD1SOSTMTHFD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109349-A1 | IMPROVED REGIMEN FOR TREATING CANCER WITH 5-FLUOROURACIL, 5,10-METHYLENETETRAHYDROFOLATE AND CAPECITABINE | ADVENTRX PHARMACEUTICALS, INC. (US) | 2008-09-12 | — | — | WO | disclosed |