Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL454802 | 1.00 | RIPK1 (0.44) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL454071 | 1.00 | RIPK1 (0.44) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL454745 | 0.84 | RIPK1 (0.46) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL457570 | 0.84 | RIPK1 (0.46) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL454486 | 0.84 | RIPK1 (0.46) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL455586 | 0.77 | RIPK1 (0.40) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL17848844 | 0.77 | KDM1A (0.41) | RIPK1HTR2AHTR2CDPP4KDM1A | |
| SCHEMBL17848842 | 0.77 | KDM1A (0.41) | RIPK1HTR2AHTR2CDPP4KDM1A | |
| SCHEMBL24508958 | 0.76 | MAOB (0.41) | RIPK1MAOBMAOAHTR2AHTR2C | |
| SCHEMBL17358800 | 0.75 | RIPK1 (0.61) | RIPK1MAOBMAOAPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614062-A1 | IMIDAZO [1, 2]PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012034091-A1 | IMIDAZO [1, 2] PYRIDAZIN COMPOUNDS AND COMPOSITIONS AS TRK INHIBITORS | IRM LLC (BM) | 2012-03-15 | — | — | WO | disclosed |