Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 16/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4576192 | 0.91 | GRIN2B (0.38) | GRIN2BGRIN1 | |
| SCHEMBL4906060 | 0.90 | ALDH1A1 (0.40) | GRIN2BGRIN1 | |
| SCHEMBL4591113 | 0.90 | GRIN2B (0.30) | GRIN2B | |
| SCHEMBL4575637 | 0.89 | MPO (0.35) | GRIN2BGRIN1HIF1A | |
| SCHEMBL4591362 | 0.88 | MEN1 (0.34) | GRIN2BHIF1A | |
| SCHEMBL14067527 | 0.88 | MEN1 (0.37) | GRIN2BHIF1A | |
| SCHEMBL4907397 | 0.88 | KDM4E (0.41) | GRIN2BHIF1A | |
| SCHEMBL4895083 | 0.87 | HIF1A (0.36) | GRIN2BGRIN1HIF1A | |
| SCHEMBL4576606 | 0.86 | MEN1 (0.37) | GRIN2BGRIN1HIF1A | |
| SCHEMBL4576778 | 0.86 | TACR1 (0.33) | GRIN2BHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214527-A1 | Hiv Integrase Inhibitors | SHIONOGI & CO. LTD (JP) | 2008-09-04 | — | — | US | claimed |
| EP-1910363-A2 | HIV INTEGRASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-04-16 | — | — | EP | claimed |
| WO-2007019098-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | claimed |
| EP-1910363-A2 | HIV INTEGRASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019098-A2 | HIV INTEGRASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214527-A1 | Hiv Integrase Inhibitors | API5, ING2, SAMHD1 | GRIN2B 4068/4885GRIN1 3318/4885HIF1A 3129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.