Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL45762 | 0.86 | KDM4E (0.60) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL30139987 | 0.86 | KDM4E (0.60) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL233797 | 0.85 | KMT2A (0.57) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| Benzene SCHEMBL27690342 | 0.85 | KMT2A (0.57) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL6013658 | 0.83 | KMT2A (0.55) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL10816174 | 0.82 | KDM4E (0.42) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL11793085 | 0.81 | KDM4E (0.46) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11760578 | 0.81 | GAA (0.61) | KDM4EPOLBSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL11363904 | 0.80 | KMT2A (0.65) | KDM4EPOLBSMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL11795244 | 0.80 | ALDH1A1 (0.59) | KDM4EALDH1A1HPGDGAAPDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5602161-A | ELASTASE INHIBITORS; PREVENTING AND TREATING EMPHYSEMA, ENDOTOXIN-INDUCED LUNG DISORDERS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-11 | — | — | US | claimed |
| EP-0676396-A1 | Tetrazolylphenyl pivalate derivatives and medicinal composition containing the same as effective component | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1995-10-11 | — | — | EP | claimed |
| EP-0821689-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | Drug Innovation & Design, Inc. (US) | 1998-02-04 | — | — | EP | disclosed |
| US-5602161-A | ELASTASE INHIBITORS; PREVENTING AND TREATING EMPHYSEMA, ENDOTOXIN-INDUCED LUNG DISORDERS | WAKAMOTO PHARMACEUTICAL CO., LTD. (JP) | 1997-02-11 | — | — | US | disclosed |
| WO-1996033198-A1 | TUMOR PROTEASE ACTIVATED PRODRUGS OF PHOSPHORAMIDE MUSTARD ANALOGS | DRUG INNOVATION & DESIGN, INC. (US) | 1996-10-24 | — | — | WO | disclosed |
| EP-0676396-A1 | Tetrazolylphenyl pivalate derivatives and medicinal composition containing the same as effective component | Wakamoto Pharmaceutical Co., Ltd. (JP) | 1995-10-11 | — | — | EP | disclosed |
| US-5116985-A | Protease Inhibitors, Antitrypsin Agents | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1992-05-26 | — | — | US | disclosed |
| EP-0435235-A1 | Isoquinoline derivatives and salts thereof as protease inhibitors. | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1991-07-03 | — | — | EP | disclosed |
| US-4843094-A | ELASTASE INHIBITOR | ONO PHARMACEUTICAL CO., LTD. (JP) | 1989-06-27 | — | — | US | disclosed |