Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 3/20 | 0.51 |
| ▸ | MASP2 | O00187 | 1/20 | 0.51 |
| ▸ | CFD | P00746 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | FABP4 | P15090 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL233797 | 0.98 | KMT2A (0.57) | KMT2AMAPTCTSKMEN1PKM | |
| Benzene SCHEMBL27690342 | 0.98 | KMT2A (0.57) | KMT2AMAPTCTSKMEN1PKM | |
| SCHEMBL8104027 | 0.90 | KMT2A (0.50) | KMT2AMAPTCTSKMEN1PKM | |
| SCHEMBL7902232 | 0.90 | KMT2A (0.50) | KMT2AMAPTCTSKMEN1PKM | |
| Sulfuric Acid SCHEMBL5306744 | 0.90 | KMT2A (0.50) | KMT2AMAPTCTSKMEN1PKM | |
| SCHEMBL9302227 | 0.89 | KMT2A (0.49) | KMT2AMAPTCTSKMEN1PKM | |
| Hydrochloric Acid SCHEMBL27870316 | 0.86 | KMT2A (0.50) | KMT2AMAPTCTSKMEN1PKM | |
| SCHEMBL9304069 | 0.86 | DHODH (0.50) | KMT2AMAPTCTSKMEN1PKM | |
| SCHEMBL30139987 | 0.85 | KDM4E (0.60) | KMT2AMAPTMEN1PKMLMNA | |
| SCHEMBL45762 | 0.85 | KDM4E (0.60) | KMT2AMAPTMEN1PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102491921-A | Preparation method for 4-guanidinozoic acid (4-methoxycarbonyl)-phenyl ester monomesylate | SUZHOU RUIHUI BIOMEDICAL RES DEV CT CO LTD | 2012-06-13 | — | — | CN | claimed |
| CN-111595996-A | Detection method and application of camostat mesylate related substance | 天津泰普制药有限公司 | 2020-08-28 | — | — | CN | disclosed |
| WO-2016160706-A1 | INHIBITORS OF COLLAGEN PROLYL 4-HYDROXYLASE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2016-10-06 | — | — | WO | disclosed |
| CN-104045594-A | 1,3-dihydro-1-oxo-2H-isoindole compounds and application thereof | UNIV SICHUAN | 2014-09-17 | — | — | CN | disclosed |
| CN-102603610-B | 1, 3-dihydro-1-oxo-2H-isoindole compound, preparation method and application thereof | UNIV SICHUAN | 2014-07-09 | — | — | CN | disclosed |
| CN-102659640-A | Preparation method of 1-(o-carboxyphenyl)biguanide hydrochloride | UNIV SOUTHEAST | 2012-09-12 | — | — | CN | disclosed |
| CN-102603610-A | 1, 3-dihydro-1-oxo-2H-isoindole compound, preparation method and application thereof | UNIV SICHUAN | 2012-07-25 | — | — | CN | disclosed |
| CN-102491921-A | Preparation method for 4-guanidinozoic acid (4-methoxycarbonyl)-phenyl ester monomesylate | SUZHOU RUIHUI BIOMEDICAL RES DEV CT CO LTD | 2012-06-13 | — | — | CN | disclosed |
| CN-101638373-B | Preparation method of p-biguanide benzoic acid hydrochloride | YANCHENG INST TECHNOLOGY | 2012-05-30 | — | — | CN | disclosed |
| CN-102329251-A | Method for chemically synthesizing p-guanidinobenzoic acid | BIN ZHOU | 2012-01-25 | — | — | CN | disclosed |
| CN-101638373-A | Method for preparing p-diguanidino benzoic acid hydrochloride | YANCHENG INST TECHNOLOGY | 2010-02-03 | — | — | CN | disclosed |
| EP-1633882-A1 | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PUROMYCIN-INSENSITIVE LEUCYL-SPECIFIC AMINOPEPTIDASE (PILS) | Bayer HealthCare AG (DE) | 2006-03-15 | — | — | EP | disclosed |
| EP-1631678-A1 | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KELL BLOOD GROUP ANTIGEN (KEL) | Bayer HealthCare AG (DE) | 2006-03-08 | — | — | EP | disclosed |
| WO-2004106540-A1 | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH PUROMYCIN-INSENSITIVE LEUCYL-SPECIFIC AMINOPEPTIDASE (PILS) | BAYER HEALTHCARE AG (DE) | 2004-12-09 | — | — | WO | disclosed |
| WO-2004101813-A1 | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KELL BLOOD GROUP ANTIGEN (KEL) | BAYER HEALTHCARE AG (DE) | 2004-11-25 | — | — | WO | disclosed |
| WO-2004086035-A1 | DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH HEPSIN (HPN) | BAYER HEALTHCARE AG (DE) | 2004-10-07 | — | — | WO | disclosed |
| WO-2001066771-A2 | HUMAN SERINE PROTEASE | ZYMOGENETICS, INC. (US) | 2001-09-13 | — | — | WO | disclosed |
| WO-2001038534-A2 | HUMAN SERPIN | ZYMOGENETICS, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| WO-2001038501-A2 | HUMAN SERINE PROTEASE | ZYMOGENETICS, INC. (US) | 2001-05-31 | — | — | WO | disclosed |
| US-4423069-A | Contraceptive method | UNIVERSITY OF ILLINOIS FOUNDATION (US) | 1983-12-27 | — | — | US | disclosed |