Hydrochloric Acid

Hydrochloric Acid

SCHEMBL4576476

C=Cc1cccc(C[N+](C)(C)CCCCCCCCCCCCCCCCCC)c1.[Cl-]

nearest known ligand 0.61

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 1/20 0.38
CHRM1 known ✓ P11229 1/20 0.38
CHRM3 known ✓ P20309 1/20 0.38
SLC6A2 known ✓ P23975 1/20 0.38
SLC6A3 known ✓ Q01959 1/20 0.38
KMT2A Q03164 3/20 0.61
MEN1 O00255 2/20 0.61
MAPK1 P28482 2/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
TP53 P04637 2/20 0.61
HTT P42858 5/20 0.60
DNM1 Q05193 6/20 0.59
HSP90AA1 P07900 2/20 0.51
RAD52 P43351 2/20 0.51
PSMD14 O00487 1/20 0.51
MMP2 P08253 1/20 0.51
MC4R P32245 1/20 0.51
MLNR O43193 1/20 0.38
NR1I2 O75469 1/20 0.38
ESR1 P03372 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL9615086 0.86 DNM1 (0.77) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL8722911 0.85 KMT2A (0.77) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL7760760 0.85 KMT2A (0.77) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL7766070 0.85 KMT2A (0.77) KMT2AMEN1MAPK1SMN1; SMN2TP53
Cetalkonium SCHEMBL27863874 0.85 KMT2A (0.73) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL2208780 0.82 HSP90AA1 (0.65) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL9772817 0.82 HSP90AA1 (0.65) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL475770 0.82 HSP90AA1 (0.65) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL347739 0.82 HSP90AA1 (0.65) KMT2AMEN1MAPK1SMN1; SMN2TP53
Hydrochloric Acid SCHEMBL5476974 0.82 HSP90AA1 (0.65) KMT2AMEN1MAPK1SMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080073511-A1 Structured Copolymer Supports for Use in Mass Spectrometry MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (US) 2008-03-27 US disclosed
EP-1807699-A1 STRUCTURED COPOLYMER SUPPORTS FOR USE IN MASS SPECTROMETRY MPG Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2007-07-18 EP disclosed
WO-2006048306-A1 STRUCTURED COPOLYMER SUPPORTS FOR USE IN MASS SPECTROMETRY MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2006-05-11 WO disclosed