Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
| ▸ | FABP4 | P15090 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | MMP1 | P03956 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8653117 | 0.84 | HTR6 (0.58) | ADAMTS4ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL7512674 | 0.82 | TTR (0.42) | ALDH1A1TTRFABP4CCNA2CDK2 | |
| SCHEMBL11559398 | 0.81 | TTR (0.40) | ALDH1A1TTRFABP4CCNA2CDK2 | |
| SCHEMBL4650108 | 0.78 | ALDH1A1 (0.44) | ALDH1A1CA1CA2CA9MMP1 | |
| SCHEMBL7520305 | 0.77 | HSD17B10 (0.46) | ALDH1A1TTRFABP4CCNA2CDK2 | |
| SCHEMBL7446867 | 0.76 | SLC1A3 (0.44) | ADAMTS4ALDH1A1HTR6MMP1MMP2 | |
| SCHEMBL5062929 | 0.75 | RAB9A (0.52) | ALDH1A1HTTLMNASMN1; SMN2MMP1 | |
| SCHEMBL5323369 | 0.75 | HPGD (0.49) | ADAMTS4ALDH1A1HTTLMNASMN1; SMN2 | |
| SCHEMBL7200135 | 0.75 | RAB9A (0.52) | ALDH1A1HTTLMNASMN1; SMN2MMP1 | |
| SCHEMBL5323373 | 0.75 | HPGD (0.49) | ADAMTS4ALDH1A1HTTLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020082057-A1 | INTERLEUKIN-10 POLYPEPTIDE CONJUGATES, DIMERS THEREOF, AND THEIR USES | AMBRX, INC. (US) | 2020-04-23 | — | — | WO | claimed |
| US-9763978-B2 | Pharmaceutical compositions comprising polymeric binders with non-hydrolysable covalent bonds and their use in treating celiac disease | VALORISATION-RECHERCHE, LIMITED PARTNERSHIP (CA) | 2017-09-19 | — | — | US | disclosed |
| US-20150064131-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMERIC BINDERS WITH NON-HYDROLYSABLE COVALENT BONDS AND THEIR USE IN TREATING CELIAC DISEASE | VALORISATION-RECHERCHE LIMITED PARTNERSHIP (CA) | 2015-03-05 | — | — | US | disclosed |
| US-8883133-B2 | Pharmaceutical compositions comprising polymeric binders with non-hydrolysable their use in treating celiac disease | VALORISATION-RECHERCHE LIMITED PARTNERSHIP (CA) | 2014-11-11 | — | — | US | disclosed |
| US-8784792-B2 | Pharmaceutical compositions comprising polymeric binders with non-hydrolysable covalent bonds and their use in treating celiac disease | Valorization-Recherche Limited Partnership (CA) | 2014-07-22 | — | — | US | disclosed |
| US-20120244105-A1 | Pharmaceutical Compositions Comprising Polymeric Binders with Non-Hydrolysable Covalent Bonds and Their Use in Treating Celiac Disease | VALORISATION-RECHERCHE LIMITED PARTNERSHIP (CA) | 2012-09-27 | — | — | US | disclosed |
| US-20080254099-A1 | Such as high molecular weight copolymer of hydroxyethyl methacrylate and 4-styrene sulfonic acid sodium salt; decreasing interaction of gluten or peptide degradation products with intestinal tract; breads | VALORISATION-RECHERCHE, LIMITED (CA) | 2008-10-16 | — | — | US | disclosed |
| EP-1948201-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMERIC BINDERS WITH NON-HYDROLYSABLE COVALENT BONDS AND THEIR USE IN TREATING CELIAC DISEASE | UNIVERSITE DE MONTREAL (CA) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007053935-A1 | PHARMACEUTICAL COMPOSITIONS COMPRISING POLYMERIC BINDERS WITH NON-HYDROLYSABLE COVALENT BONDS AND THEIR USE IN TREATING CELIAC DISEASE | UNIVERSITE DE MONTREAL (CA) | 2007-05-18 | — | — | WO | disclosed |