SCHEMBL457773

SCHEMBL457773

N[C@@H](CCCCNS(=O)(=O)Cc1ccccc1)C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC1A3 P43003 1/20 0.52
SLC1A2 P43004 1/20 0.52
SLC1A1 P43005 1/20 0.52
ALDH1A1 P00352 2/20 0.48
HPGD P15428 1/20 0.48
HDAC6 Q9UBN7 2/20 0.47
HDAC3 O15379 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC1 Q13547 1/20 0.47
HDAC7 Q8WUI4 1/20 0.47
HDAC2 Q92769 1/20 0.47
HDAC10 Q969S8 1/20 0.47
HDAC11 Q96DB2 1/20 0.47
HDAC8 Q9BY41 1/20 0.47
HDAC9 Q9UKV0 1/20 0.47
HDAC5 Q9UQL6 1/20 0.47
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
ALPI P09923 1/20 0.46
PKM P14618 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27638669 0.91 SLC1A3 (0.45) SLC1A3SLC1A2SLC1A1ALDH1A1HPGD
SCHEMBL14615873 0.81 ALDH1A1 (0.63) SLC1A3SLC1A2SLC1A1ALDH1A1HDAC3
SCHEMBL3448866 0.81 ALDH1A1 (0.63) SLC1A3SLC1A2SLC1A1ALDH1A1HDAC3
SCHEMBL6734115 0.80 SLC1A3 (0.59) SLC1A3SLC1A2SLC1A1HPGDALPI
SCHEMBL6734110 0.80 SLC1A3 (0.59) SLC1A3SLC1A2SLC1A1HPGDALPI
Hydrochloric Acid SCHEMBL7461056 0.79 SLC1A3 (0.57) SLC1A3SLC1A2SLC1A1HPGDALPI
Hydrochloric Acid SCHEMBL7461064 0.79 SLC1A3 (0.57) SLC1A3SLC1A2SLC1A1HPGDALPI
SCHEMBL7291294 0.78 DPP7 (0.54) SLC1A3SLC1A2SLC1A1ALDH1A1HPGD
SCHEMBL7291298 0.78 DPP7 (0.54) SLC1A3SLC1A2SLC1A1ALDH1A1HPGD
SCHEMBL1976382 0.78 DPP8 (0.66) SLC1A1ALDH1A1HDAC3HDAC1HDAC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4243869-A1 BI-SPECIFIC ANTIBODIES COMPRISING ANTI-CD137 BINDING MOLECULES Lyvgen Biopharma Holdings Limited (KY) 2023-09-20 EP disclosed
EP-4048701-A1 ANTI-CD40 BINDING MOLECULES AND BI-SPECIFIC ANTIBODIES COMPRISING SUCH Lyvgen Biopharma Holdings Limited (KY) 2022-08-31 EP disclosed
WO-2022103780-A1 BI-SPECIFIC ANTIBODIES COMPRISING ANTI-CD137 BINDING MOLECULES LYVGEN BIOPHARMA HOLDINGS LIMITED (KY) 2022-05-19 WO disclosed
WO-2021081303-A1 ANTI-CD40 BINDING MOLECULES AND BI-SPECIFIC ANTIBODIES COMPRISING SUCH Lyvgen Biopharma (Suzhou) Co., Ltd. (CN) 2021-04-29 WO disclosed
EP-3240570-A1 BISPECIFIC ANTIBODIES AGAINST PLASMA KALLIKREIN AND FACTOR XII Dyax Corp. (US) 2017-11-08 EP disclosed
WO-2016109774-A1 BISPECIFIC ANTIBODIES AGAINST PLASMA KALLIKREIN AND FACTOR XII DYAX CORP. (US) 2016-07-07 WO disclosed
EP-2640745-A2 ANTIBODY DERIVATIVES Allozyne, Inc. (US) 2013-09-25 EP disclosed
WO-2012032181-A9 ANTIBODY DERIVATIVES ALLOZYNE, INC (US) 2013-06-13 WO disclosed
WO-2012032181-A2 NOVEL ANTIBODY DERIVATIVES ALLOZYNE, INC (US) 2012-03-15 WO disclosed