SCHEMBL4577783

SCHEMBL4577783

C[Si](C)(N[SiH3])c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.39
ESR2 Q92731 1/20 0.39
TSHR P16473 2/20 0.38
NR1H2 P55055 2/20 0.32
NR1H3 Q13133 2/20 0.32
CA4 P22748 1/20 0.32
MAPT P10636 1/20 0.31
LMNA P02545 1/20 0.30
ALOX12 P18054 1/20 0.30
ACHE P22303 1/20 0.30
GPR3 P46089 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL842024 0.78 ESR1 (0.42) ESR1ESR2TSHRNR1H2NR1H3
SCHEMBL2275514 0.76 ESR1 (0.41) ESR1ESR2TSHRNR1H2NR1H3
SCHEMBL16860017 0.74 ESR1 (0.39) ESR1ESR2TSHRNR1H2NR1H3
SCHEMBL7037975 0.74 ESR1 (0.39) ESR1ESR2TSHRNR1H2NR1H3
SCHEMBL2509044 0.72 TSHR (0.35) ESR1ESR2TSHRALOX12
SCHEMBL29757964 0.72 ESR1 (0.38) ESR1ESR2TSHRNR1H2NR1H3
SCHEMBL2273250 0.72 ESR1 (0.38) ESR1ESR2NR1H2NR1H3MAPT
SCHEMBL2200402 0.72 TSHR (0.42) ESR1ESR2TSHRMAPTLMNA
SCHEMBL3152396 0.72 ESR1 (0.38) ESR1ESR2TSHRNR1H2NR1H3
SCHEMBL11906333 0.71 ESR1 (0.46) ESR1ESR2TSHRNR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080057717-A1 SEMICONDUCTOR DEVICE MANUFACTURING METHOD FUJITSU LIMITED (JP) 2008-03-06 US disclosed