SCHEMBL4577829

SCHEMBL4577829

COC(=O)c1ccc(Br)cc1C(=O)OC

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 1/20 0.56
GAA P10253 3/20 0.54
ALDH1A1 P00352 2/20 0.54
L3MBTL1 Q9Y468 1/20 0.51
HSD17B10 Q99714 2/20 0.50
CA12 O43570 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
CA14 Q9ULX7 2/20 0.50
SLC6A3 Q01959 1/20 0.50
PDK2 Q15119 1/20 0.50
PDK4 Q16654 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.48
HPGD P15428 3/20 0.47
CASP1 P29466 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GLA P06280 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29773857 1.00 NR4A2 (0.56) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL23526183 0.90 TSHR (0.52) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL6072552 0.90 ALDH1A1 (0.54) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL24252797 0.90 TSHR (0.52) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL16961315 0.90 NR4A2 (0.51) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL6072149 0.90 ALDH1A1 (0.54) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL7370270 0.89 DGAT1 (0.53) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL6071892 0.87 NR4A2 (0.49) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL6072378 0.87 NR4A2 (0.49) NR4A2GAAALDH1A1L3MBTL1HSD17B10
SCHEMBL861495 0.86 PTPN2 (0.54) NR4A2GAAALDH1A1L3MBTL1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 178 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120081801-A Tetracarboxylic acid organic ligand based on benzothiadiazole functional group for preparing metal organic framework, and preparation method and application thereof 江西理工大学 2025-06-03 CN claimed
CN-118082333-A Multilayer antibacterial SPC board and preparation process thereof 福建福晟新材料科技有限公司 2024-05-28 CN claimed
CN-117486843-A Preparation method of 3,3', 4' -biphenyl tetracarboxylic dianhydride 大连理工大学 2024-02-02 CN claimed
EP-2617471-B1 FIRE EXTINGUISHING COMPOSITION GENERATING FIRE EXTINGUISHING SUBSTANCE BY HIGH TEMPERATURE SUBLIMATION XIAN WESTPEACE FIRE TECH CO LTD (CN) 2018-12-12 EP claimed
US-8865014-B2 Fire extinguishing composition generating fire extinguishing substance by high temperature sublimation XI'AN J&R FIRE FIGHTING EQUIPMENT CO., LTD. (CN) 2014-10-21 US claimed
EP-2617471-A1 FIRE EXTINGUISHING COMPOSITION PRODUCING FIRE EXTINGUISHING SUBSTANCE BY HIGH TEMPERATURE SUBLIMATION Shaanxi J&R Fire Fighting Co., Ltd. (CN) 2013-07-24 EP claimed
US-20130168593-A1 FIRE EXTINGUISHING COMPOSITION GENERATING FIRE EXTINGUISHING SUBSTANCE BY HIGH TEMPERATURE SUBLIMATION SHAANXI J&R FIRE FIGHTING CO., LTD. (CN) 2013-07-04 US claimed
US-20260132133-A1 MACROCYCLIC HETEROCYCLES AND USES THEREOF KUMQUAT BIOSCIENCES INC (US) 2026-05-14 US disclosed
EP-4736882-A2 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE Cullgen (Shanghai), Inc. (CN) 2026-05-06 EP disclosed
US-12559486-B2 Tau-protein targeting compounds and associated methods of use ARVINAS OPERATIONS, INC. (US) 2026-02-24 US disclosed
EP-3841098-B1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2026-01-14 EP disclosed
US-20260008770-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF INSILICO MEDICINE IP LTD (HK) 2026-01-08 US disclosed
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE CULLGEN SHANGHAI INC (CN) 2025-12-25 US disclosed
WO-1999065877-A1 THERAPEUTIC BIARYL DERIVATIVES GLAXO GROUP LIMITED (GB) 1999-12-23 WO disclosed
US-5968908-A Restricted 9-cis retinoids AMERICAN CYANAMID COMPANY (US) 1999-10-19 US disclosed
US-5880309-A DIALKYL DIALKOXYCARBONYLPHENYL PHOSPHONATES USEFUL AS RESIN MODIFIERS PRODUCED AT HIGH YIELD AND LOW COST BY HEATING A TRIALKYL PHOSPHITE AND A DIALKOXYCARBONYLPHENYL HALIDE IN THE PRESENCE OF A PALLADIUM OR NICKEL CATALYST AND HYDROLYZING NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1999-03-09 US disclosed
EP-0855400-A1 Phenylphosphonic acid derivative and production process therefor NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1998-07-29 EP disclosed
CN-1174833-A Phenyl substituted alkenocarboxylic guanidine, preparation method, application as medicine or diagnostic agent adn medicine containing it HOECHST AG (DE) 1998-03-04 CN disclosed
EP-0825178-A1 Phenyl-substituted alkenoylguanidides, process for their preparation, their use as drugs or in diagnostic agents and drugs containing them HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-25 EP disclosed
EP-0718285-A2 Restricted 9-cis-retinoids American Cyanamid Company (US) 1996-06-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008770-A1 CBL-B INHIBITORS AND METHODS OF USES THEREOF CBL, CBLC, CBLB NR4A2 1527/4885GAA 2330/4885ALDH1A1 2038/4885
US-20250388587-A1 TROPOMYOSIN RECEPTOR KINASE (TRK) DEGRADATION COMPOUNDS AND METHODS OF USE ERBB2, MUSK, ERBB3 NR4A2 240/4885GAA 3090/4885ALDH1A1 4483/4885
US-20260132133-A1 MACROCYCLIC HETEROCYCLES AND USES THEREOF KRAS, HRAS, BCL6 NR4A2 2701/4885GAA 4600/4885ALDH1A1 3584/4885
US-12559486-B2 Tau-protein targeting compounds and associated methods of use UBQLN2, UBQLN1, CRBN NR4A2 2812/4885GAA 2087/4885ALDH1A1 3566/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.