Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 4/20 | 0.74 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CCR2 | P41597 | 2/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.58 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4579161 | 0.92 | CCR3 (0.71) | CCR3ROCK2ROCK1GRIN2BALDH1A1 | |
| SCHEMBL4578305 | 0.90 | CHRNB2 (0.69) | CCR3ROCK2ROCK1GRIN2BCCR2 | |
| SCHEMBL6702434 | 0.85 | CCR3 (1.00) | CCR3ROCK2ROCK1GRIN2BCCR2 | |
| SCHEMBL5419708 | 0.84 | ROCK2 (0.75) | CCR3ROCK2ROCK1GRIN2BCCR2 | |
| SCHEMBL6701940 | 0.83 | CCR3 (1.00) | CCR3ROCK2ROCK1GRIN2BCCR2 | |
| SCHEMBL4577729 | 0.83 | CCR3 (0.59) | CCR3GRIN2BALDH1A1CHRNB2CHRNB4 | |
| SCHEMBL4577779 | 0.81 | CCR3 (0.64) | CCR3ROCK2ROCK1GRIN2BCCR2 | |
| SCHEMBL5413607 | 0.81 | CHRNB2 (0.66) | ROCK2ROCK1ALDH1A1CCR2CHRNB2 | |
| SCHEMBL4551769 | 0.81 | GRIN1 (0.71) | GRIN2BALDH1A1GRIN1 | |
| SCHEMBL4577935 | 0.80 | ALDH1A1 (0.61) | CCR3GRIN2BALDH1A1GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7435744-B2 | Piperidine derivatives as NMDA receptor antagonists | GEDEON RICHTER VEGYESZETI GYAR RT (HU) | 2008-10-14 | — | — | US | disclosed |
| CN-100413860-C | piperidine derivatives as NMDA receptor antagonists | HUNGARY GIREL GYOGYSZERGYAR (HU) | 2008-08-27 | — | — | CN | disclosed |
| CN-1556805-A | piperidine derivatives as NMDA receptor antagonists | ������ҩ������˾ | 2004-12-22 | — | — | CN | disclosed |
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | UCB Biopharma SRL (BE) | 2004-08-12 | — | — | US | disclosed |
| EP-1409477-A1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003010159-A1 | PIPERIDINE DERIVATIVES AS NMDA RECEPTOR ANTAGONISTS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-02-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040157886-A1 | Piperdine derivatives as NMDA receptor antagonists | GRIN1, GRIN2D, GRIN2C | CCR3 672/4885ROCK2 4291/4885ROCK1 3751/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.