Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 4/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | MITF | O75030 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.33 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.33 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786517 | 0.98 | PTGS1 (0.42) | MGLLPTGS1PTGS2FAAHNPC1 | |
| Alcohol SCHEMBL28659728 | 0.94 | NPC1 (0.36) | MGLLPTGS1PTGS2FAAHNPC1 | |
| Hydrochloric Acid SCHEMBL1471336 | 0.94 | PTGS1 (0.39) | MGLLPTGS1PTGS2FAAHNPC1 | |
| SCHEMBL13493092 | 0.82 | — | — | |
| SCHEMBL18838747 | 0.82 | NPC1 (0.44) | MGLLPTGS1PTGS2FAAHNPC1 | |
| SCHEMBL4270831 | 0.79 | TSHR (0.47) | MGLLPTGS1PTGS2FAAHNPC1 | |
| SCHEMBL4270037 | 0.79 | TSHR (0.47) | MGLLPTGS1PTGS2FAAHNPC1 | |
| SCHEMBL4274617 | 0.79 | TSHR (0.47) | MGLLPTGS1PTGS2FAAHNPC1 | |
| SCHEMBL7204901 | 0.75 | NPC1 (0.41) | MGLLPTGS1PTGS2FAAHNPC1 | |
| SCHEMBL665738 | 0.75 | NPC1 (0.43) | MGLLPTGS1PTGS2FAAHNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002231-A1 | 1-N-aryl-1,4-dihydropyridines, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1979-06-13 | — | — | EP | claimed |
| EP-2576536-B1 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | UNIV QUEENSLAND (AU) | 2016-09-14 | — | — | EP | disclosed |
| US-9199976-B2 | Haematopoietic-prostaglandin D2 synthase inhibitors | THE UNIVERSITY OF QUEENSLAND (AU) | 2015-12-01 | — | — | US | disclosed |
| US-20130137684-A1 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2013-05-30 | — | — | US | disclosed |
| EP-2576536-A2 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | The University of Queensland (AU) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011150457-A2 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | THE UNIVERSITY OF QUEENSLAND (AU) | 2011-12-08 | — | — | WO | disclosed |
| WO-2008116913-A2 | PEPTIDE COMPOUNDS WITH TRANSIENT BIODEGRADABLE PEGYLATION | NOVO NORDISK A/S (DK) | 2008-10-02 | — | — | WO | disclosed |
| US-5942526-A | TREATMENT OF NERVOUS SYSTEM DISORDERS; SELECTIVE POTASSIUM CHANNEL MODULATORS | BAYER AKTIENGESELLSCHAFT (DE) | 1999-08-24 | — | — | US | disclosed |
| EP-0717036-B1 | Use of 5-acyl-1,4-dihydropyridines for the treatment of diseases of the CNS | BAYER AG (DE) | 1999-03-17 | — | — | EP | disclosed |
| US-5646166-A | POTASSIUM CHANNEL MODULATORS, TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-08 | — | — | US | disclosed |
| US-5008390-A | Compounds for preparing 6-phenyl-2,3-dihydroimidazo[2,1-b]-thiazoles and corresponding thiazines | SMITHKLINE BECKMAN CORPORATION (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0321490-A4 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES. | SMITHKLINE BECKMAN CORP (US) | 1990-05-14 | — | — | EP | disclosed |
| EP-0321490-A1 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES. | SMITHKLINE BECKMAN CORP (US) | 1989-06-28 | — | — | EP | disclosed |
| US-4803279-A | 1.4-dihydro-4-pyridyl-substituted imidazo (2,1-b) thiazoles and the corresponding thiazines. | SMITHKLINE BECKMAN CORPORATION (US) | 1989-02-07 | — | — | US | disclosed |
| WO-1988001169-A1 | INHIBITION OF INTERLEUKIN-1 PRODUCTION BY MONOCYTES AND/OR MACROPHAGES | SMITHKLINE BECKMAN CORPORATION (US) | 1988-02-25 | — | — | WO | disclosed |
| EP-0231622-A2 | Inhibition of the 5-lipoxygenase pathway | SMITHKLINE BEECHAM CORPORATION (US) | 1987-08-12 | — | — | EP | disclosed |
| EP-0203787-A2 | Process for preparing pyridyl-substituted imidazo[2,1-b]thiazoles and thiazines | SMITHKLINE BEECHAM CORPORATION (US) | 1986-12-03 | — | — | EP | disclosed |
| EP-0002231-A1 | 1-N-aryl-1,4-dihydropyridines, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |
| EP-0002231-A1 | 1-N-aryl-1,4-dihydropyridines, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |
| EP-0002231-A1 | 1-N-aryl-1,4-dihydropyridines, process for their preparation and their pharmaceutical application | BAYER AG (DE) | 1979-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137684-A1 | HAEMATOPOIETIC-PROSTAGLANDIN D2 SYNTHASE INHIBITORS | HPGDS, PTGES, PTGIS | MGLL 589/4885PTGS1 5/4885PTGS2 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.