Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 10/20 | 0.61 |
| ▸ | AKT1 | P31749 | 7/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.42 |
| ▸ | PRKACA | P17612 | 2/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.42 |
| ▸ | LATS1 | O95835 | 1/20 | 0.42 |
| ▸ | PRKACB | P22694 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | GRK2 | P25098 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | SGK3 | Q96BR1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16432987 | 0.88 | AKT2 (0.76) | AKT2AKT1ROCK2ACVR1AKT3 | |
| SCHEMBL15689115 | 0.88 | AKT2 (0.76) | AKT2AKT1ROCK2ACVR1AKT3 | |
| SCHEMBL3740850 | 0.80 | AKT2 (0.70) | AKT2AKT1ROCK2ACVR1PIM1 | |
| SCHEMBL16872766 | 0.79 | AKT2 (0.95) | AKT2AKT1ROCK2PIM1ILK | |
| SCHEMBL15504532 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ACVR1PRKCD | |
| SCHEMBL20588075 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ACVR1AKT3 | |
| SCHEMBL104535 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ACVR1ROCK1 | |
| SCHEMBL28424886 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ACVR1AKT3 | |
| SCHEMBL1188308 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2AKT3PRKACA | |
| SCHEMBL844167 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ACVR1PRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11065235-B2 | Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2021-07-20 | — | — | US | disclosed |
| EP-3625232-B1 | SUBSTITUTED METHANOPYRIDO [2, 1-A]ISOINDOLONES AS MACHR MODULATORS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS AND PROCESS FOR PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2021-06-23 | — | — | EP | disclosed |
| US-20200121657-A1 | SUBSTITUTED METHANOPYRIDO [2, 1-a] ISOINDOLONES AS mAChR MODULATORS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2020-04-23 | — | — | US | disclosed |
| EP-3625232-A1 | SUBSTITUTED METHANOPYRIDO [2, 1-A]ISOINDOLONESAS MACHR MODULATORS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS AND PROCESS FOR PREPARATION THEREOF | Council of Scientific and Industrial Research (IN) | 2020-03-25 | — | — | EP | disclosed |
| WO-2018211530-A1 | SUBSTITUTED METHANOPYRIDO [2, 1-A] ISOINDOLONESAS MACHR MODULATORS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2018-11-22 | — | — | WO | disclosed |
| US-9012445-B2 | Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors | VANDERBILT UNIVERSITY (US) | 2015-04-21 | — | — | US | disclosed |
| US-9012445-B2 | Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors | VANDERBILT UNIVERSITY (US) | 2015-04-21 | — | — | US | disclosed |
| US-9012445-B2 | Substituted 4-(1H-pyrazol-4-yl)benzyl analogues as positive allosteric modulators of mAChR M1 receptors | VANDERBILT UNIVERSITY (US) | 2015-04-21 | — | — | US | disclosed |
| US-20140206676-A1 | SUBSTITUTED 4-(1H-PYRAZOL-4-YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140206676-A1 | SUBSTITUTED 4-(1H-PYRAZOL-4-YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2014-07-24 | — | — | US | disclosed |
| WO-2013106795-A1 | SUBSTITUTED 4-(1H~PYRAZOL-4.YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-07-18 | — | — | WO | disclosed |
| WO-2013106795-A1 | SUBSTITUTED 4-(1H~PYRAZOL-4.YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2013-07-18 | — | — | WO | disclosed |
| US-8362017-B2 | N-[5-chloro-2-(methyloxy)phenyl]-2-{[3-(1H-tetrazol-1-yl)phenyl]oxy}acetamide; antiproliferative agents; protein kinase inhibitors; drug screening | EXELIXIS, INC. (US) | 2013-01-29 | — | — | US | disclosed |
| US-20080096892-A1 | C-Kit Modulators And Methods Of Use | EXELIXIS, INC. (US) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096892-A1 | C-Kit Modulators And Methods Of Use | KIT, PRKCH, PRKCB | AKT2 94/4885AKT1 36/4885ROCK2 295/4885 |
| US-20140206676-A1 | SUBSTITUTED 4-(1H-PYRAZOL-4-YL)BENZYL ANALOGUES AS POSITIVE ALLOSTERIC MODULATORS OF MACHR M1 RECEPTORS | CHRM1, CHRM4, CHRM5 | AKT2 3203/4885AKT1 2199/4885ROCK2 1452/4885 |
| US-20200121657-A1 | SUBSTITUTED METHANOPYRIDO [2, 1-a] ISOINDOLONES AS mAChR MODULATORS FOR TREATING VARIOUS ASSOCIATED PATHOPHYSIOLOGICAL CONDITIONS AND PROCESS FOR PREPARATION THEREOF | CHRM3, CHRM5, ADRB1 | AKT2 4311/4885AKT1 4096/4885ROCK2 1817/4885 |
| US-11065235-B2 | Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof | CHRM1, CHRM3, CHRM5 | AKT2 4312/4885AKT1 4035/4885ROCK2 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.