Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 7/20 | 0.61 |
| ▸ | AKT1 | P31749 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 8/20 | 0.51 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.50 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16432987 | 0.88 | AKT2 (0.76) | AKT2AKT1ROCK2ROCK1ACVR1 | |
| SCHEMBL15689115 | 0.88 | AKT2 (0.76) | AKT2AKT1ROCK2ROCK1ACVR1 | |
| SCHEMBL27674394 | 0.82 | AKT2 (0.56) | AKT2AKT1ROCK2ROCK1MYLK4 | |
| SCHEMBL3740850 | 0.80 | AKT2 (0.70) | AKT2AKT1ROCK2ACVR1 | |
| SCHEMBL9977893 | 0.79 | AKT1 (0.48) | AKT2AKT1ROCK2PDPK1 | |
| SCHEMBL30737880 | 0.79 | AKT1 (0.48) | AKT2AKT1ROCK2PDPK1 | |
| SCHEMBL16872766 | 0.79 | AKT2 (0.95) | AKT2AKT1ROCK2 | |
| SCHEMBL1978062 | 0.78 | ROCK2 (0.55) | AKT2AKT1ROCK2ROCK1MYLK4 | |
| SCHEMBL20588075 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ROCK1ACVR1 | |
| SCHEMBL4582237 | 0.77 | AKT2 (0.61) | AKT2AKT1ROCK2ROCK1ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003051906-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-26 | — | — | WO | claimed |
| US-12358878-B2 | N-aromatic amide compounds, preparation methods and uses thereof | SHENZHEN EDK PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2025-07-15 | — | — | US | disclosed |
| CN-119654324-A | Novel compounds as hypoxia inducible factor 1 (HIF-1) inhibitors or Vascular Endothelial Growth Factor (VEGF) inhibitors and pharmaceutical compositions comprising the same | 株式会社次代生物科学 | 2025-03-18 | — | — | CN | disclosed |
| US-12215086-B2 | Selective androgen receptor degrader (SARD) ligands and methods of use thereof | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2025-02-04 | — | — | US | disclosed |
| EP-3858811-B1 | N-AROMATIC AMIDES COMPOUND AND PREPARATION METHOD AND USE THEREOF | SHENZHEN EDK PHARMACEUTICAL TECH CO LTD (CN) | 2024-07-17 | — | — | EP | disclosed |
| US-20230382870-A1 | N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | SHENZHEN EDK PHARMACEUTICAL TECH CO LTD (CN) | 2023-11-30 | — | — | US | disclosed |
| US-20230382870-A1 | N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | SHENZHEN EDK PHARMACEUTICAL TECH CO LTD (CN) | 2023-11-30 | — | — | US | disclosed |
| US-20230382870-A1 | N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | SHENZHEN EDK PHARMACEUTICAL TECH CO LTD (CN) | 2023-11-30 | — | — | US | disclosed |
| US-11760727-B2 | N-aromatic amide compounds, preparation methods and uses thereof | SHENZHEN EDK PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-09-19 | — | — | US | disclosed |
| US-11760727-B2 | N-aromatic amide compounds, preparation methods and uses thereof | SHENZHEN EDK PHARMACEUTICAL TECHNOLOGY CO., LTD. (CN) | 2023-09-19 | — | — | US | disclosed |
| WO-2010007966-A1 | AZOLE COMPOUND | アステラス製薬株式会社 (JP) | 2010-01-21 | — | — | WO | disclosed |
| US-20090124625-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2009-05-14 | — | — | US | disclosed |
| CN-101365692-A | Novel antifungal triazole derivatives | DAE WOONG PHARMA (KR) | 2009-02-11 | — | — | CN | disclosed |
| US-20080287440-A1 | Novel Antifungal Triazole Derivatives | DAEWOONG PHARMACEUTIDCAL CO., LTD. (KR) | 2008-11-20 | — | — | US | disclosed |
| EP-1951705-A1 | NOVEL ANTIFUNGAL TRIAZOLE DERIVATIVES | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2008-08-06 | — | — | EP | disclosed |
| CN-101001846-A | Novel alkynyl derivatives as modulators of metabotropic glutamate receptors | ADDEX PHARMACEUTICALS SA (CH) | 2007-07-18 | — | — | CN | disclosed |
| WO-2007052943-A1 | NOVEL ANTIFUNGAL TRIAZOLE DERIVATIVES | DAEWOONG PHARMACEUTICAL CO., LTD. (KR) | 2007-05-10 | — | — | WO | disclosed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123703-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMACEUTICALS SA (CH) | 2005-12-29 | — | — | WO | disclosed |
| WO-2003051906-A2 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-06-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124625-A1 | NOVEL ALKYNYL DERIVATIVES AS MODULATORS OF METATROPIC GLUTAMATE RECEPTORS | GRM5, GRM2, GRM1 | AKT2 2795/4885AKT1 2934/4885ROCK2 2959/4885 |
| US-12215086-B2 | Selective androgen receptor degrader (SARD) ligands and methods of use thereof | AR, BRCA1, AHR | AKT2 4119/4885AKT1 3478/4885ROCK2 4230/4885 |
| US-20230382870-A1 | N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF | H1-3, H1-0, NAT1 | AKT2 3756/4885AKT1 3507/4885ROCK2 3414/4885 |
| US-11760727-B2 | N-aromatic amide compounds, preparation methods and uses thereof | AR, BPHL, CYP19A1 | AKT2 2576/4885AKT1 2749/4885ROCK2 2819/4885 |
| US-20080287440-A1 | Novel Antifungal Triazole Derivatives | CYP51A1, ERG28, CYP3A43 | AKT2 3444/4885AKT1 3851/4885ROCK2 3466/4885 |
| US-12358878-B2 | N-aromatic amide compounds, preparation methods and uses thereof | H1-3, H1-0, NAT1 | AKT2 3756/4885AKT1 3507/4885ROCK2 3414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.