Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 6/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.37 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242820 | 0.93 | PIK3C3 (0.40) | CYP2C19PIK3C3HTR6POLBL3MBTL1 | |
| SCHEMBL4582645 | 0.87 | CYP2C19 (0.42) | CYP2C19PIK3C3HTR6L3MBTL1DRD2 | |
| SCHEMBL4582735 | 0.86 | CYP2C19 (0.41) | CYP2C19PIK3C3HTR6L3MBTL1DRD2 | |
| SCHEMBL4584711 | 0.84 | PIK3C3 (0.40) | CYP2C19PIK3C3HTR6L3MBTL1MEN1 | |
| SCHEMBL4612732 | 0.84 | PIK3C3 (0.42) | CYP2C19PIK3C3HTR6L3MBTL1MEN1 | |
| SCHEMBL4582702 | 0.78 | HTR6 (0.36) | PIK3C3HTR6POLBMEN1KMT2A | |
| SCHEMBL4591926 | 0.76 | AKT1 (0.43) | CYP2C19PIK3C3HTR6L3MBTL1 | |
| SCHEMBL8242841 | 0.74 | PIK3C3 (0.33) | PIK3C3HTR6MEN1KMT2A | |
| SCHEMBL4633196 | 0.73 | CYP2C19 (0.46) | CYP2C19PIK3C3HTR6POLBL3MBTL1 | |
| SCHEMBL27848203 | 0.72 | CYP2C19 (0.45) | CYP2C19PIK3C3HTR6L3MBTL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |