Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.37 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27848203 | 0.83 | CYP2C19 (0.45) | CYP2C19KDM4EHTR6ALDH1A1MET | |
| SCHEMBL10125007 | 0.81 | L3MBTL1 (0.44) | PIK3C3MEN1KMT2AENPP3PKM | |
| SCHEMBL4583522 | 0.79 | AKT1 (0.41) | CYP2C19PIK3C3ENPP3ENPP1L3MBTL1 | |
| SCHEMBL8242925 | 0.78 | PIK3C3 (0.42) | CYP2C19HTR6PIK3C3MEN1POLB | |
| SCHEMBL4592678 | 0.77 | AKT1 (0.46) | CYP2C19PIK3C3 | |
| SCHEMBL4593041 | 0.76 | CYP2C19 (0.47) | CYP2C19HPGDHTR6ALDH1A1MET | |
| SCHEMBL4582645 | 0.76 | CYP2C19 (0.42) | CYP2C19HTR6METPIK3C3ENPP3 | |
| SCHEMBL8233993 | 0.75 | AKT1 (0.45) | HTR6PIK3C3MEN1POLBKMT2A | |
| SCHEMBL8243099 | 0.75 | AKT1 (0.47) | L3MBTL1 | |
| SCHEMBL4582735 | 0.75 | CYP2C19 (0.41) | CYP2C19HTR6METPIK3C3ENPP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |