SCHEMBL4582636

SCHEMBL4582636

Cc1ccc(C2=C(c3c(F)cccc3F)C(=O)OC2(C)O)nc1C

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PTGS2 P35354 14/20 0.37
PTGS1 P23219 4/20 0.35
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
BRD4 O60885 1/20 0.30
HCAR3 P49019 1/20 0.30
HCAR2 Q8TDS4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4583529 0.85 PTGS2 (0.37) PTGS2PTGS1
SCHEMBL10015964 0.75 PTGS2 (0.56) PTGS2PTGS1CA1CA2CA7
SCHEMBL4583693 0.74 PTGS2 (0.47) PTGS2PTGS1CA1CA2CA7
SCHEMBL4583216 0.73 PTGS2 (0.52) PTGS2PTGS1CA1CA2CA7
SCHEMBL2350613 0.72 PTGS2 (0.60) PTGS2PTGS1
SCHEMBL4582866 0.68 ADORA2A (0.40) PTGS2PTGS1CA1CA2CA7
SCHEMBL2351999 0.66 PTGS2 (0.56) PTGS2PTGS1
SCHEMBL19446292 0.66 PTGS2 (0.55) PTGS2PTGS1
SCHEMBL1868853 0.65 PTGS2 (0.46) PTGS2PTGS1
SCHEMBL4583249 0.64 PTGS2 (0.40) PTGS2PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1972623-A1 Arylpyridazines as fungicides Bayer CropScience AG (DE) 2008-09-24 EP disclosed