Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.40 |
| ▸ | HTR3B | O95264 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.40 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.40 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6947266 | 0.81 | PLG (0.44) | KMT2AALDH1A1USP2NOS1NOS3 | |
| SCHEMBL7898821 | 0.79 | HTR3E (0.50) | KMT2AGAAMAPTALDH1A1HTR3E | |
| SCHEMBL11238996 | 0.76 | ALDH1A1 (0.68) | KMT2AGAAMAPTALDH1A1HTR3E | |
| SCHEMBL3635852 | 0.73 | KMT2A (0.45) | KMT2AGAAMAPTALDH1A1HTR3E | |
| SCHEMBL7256704 | 0.73 | ADRA2A (0.49) | KMT2AMAPTALDH1A1USP2PLAU | |
| SCHEMBL7256700 | 0.73 | ADRA2A (0.49) | KMT2AMAPTALDH1A1USP2PLAU | |
| SCHEMBL10779753 | 0.72 | CYP19A1 (0.43) | KMT2AMAPTALDH1A1NOS1NOS3 | |
| SCHEMBL3287572 | 0.72 | SMN1; SMN2 (0.69) | KMT2AGAAMAPTALDH1A1USP2 | |
| SCHEMBL3287569 | 0.72 | SMN1; SMN2 (0.69) | KMT2AGAAMAPTALDH1A1USP2 | |
| SCHEMBL13325330 | 0.72 | SMN1; SMN2 (0.69) | KMT2AGAAMAPTALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968947-A1 | GABA-B RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-09-17 | — | — | EP | claimed |
| WO-2007073300-A1 | GABA-B RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | claimed |
| EP-1761531-A1 | IMIDAZOLE VARIANTS AS MODULATORS OF GABA RECEPTOR FOR THE TREATMENT OF GI DISORDERS | AstraZeneca AB (SE) | 2007-03-14 | — | — | EP | disclosed |
| WO-2006001750-A1 | IMIDAZOLE VARIANTS AS MODULATORS OF GABA RECEPTOR FOR THE TREATMENT OF GI DISORDERS | ASTRAZENECA AB (SE) | 2006-01-05 | — | — | WO | disclosed |