Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CAMKK2 | Q96RR4 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | MELK | Q14680 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | MYLK4 | Q86YV6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241818 | 0.93 | AKT1 (0.60) | AKT1ROCK1CYP3A4CAMKK2DYRK1A | |
| SCHEMBL8239659 | 0.87 | AKT1 (0.70) | AKT1ROCK1DYRK1AMAP4K4CDK8 | |
| SCHEMBL8234027 | 0.85 | AKT1 (0.57) | AKT1ROCK1CYP3A4CAMKK2DYRK1A | |
| SCHEMBL8233616 | 0.83 | AKT1 (0.76) | AKT1ROCK1CYP3A4CAMKK2DYRK1A | |
| SCHEMBL8235518 | 0.81 | AKT1 (0.77) | AKT1ROCK1DYRK1AMAP4K4MELK | |
| SCHEMBL4582325 | 0.81 | AKT1 (0.45) | AKT1ROCK1CYP3A4ROCK2MYLK4 | |
| SCHEMBL8234017 | 0.80 | AKT1 (0.61) | AKT1ROCK1DYRK1AMAP4K4CDK8 | |
| SCHEMBL8239665 | 0.79 | AKT1 (0.58) | AKT1ROCK1CAMKK2DYRK1ACDC7 | |
| SCHEMBL4584895 | 0.78 | AKT1 (1.00) | AKT1ROCK1CAMKK2DYRK1AMAP4K4 | |
| SCHEMBL4593757 | 0.78 | ROCK1 (0.65) | AKT1ROCK1CYP3A4CAMKK2DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |