Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 13/20 | 1.00 |
| ▸ | AKT2 | P31751 | 2/20 | 0.54 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.54 |
| ▸ | MMP3 | P08254 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | MMP8 | P22894 | 1/20 | 0.51 |
| ▸ | MMP12 | P39900 | 1/20 | 0.51 |
| ▸ | MMP13 | P45452 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.46 |
| ▸ | NEK4 | P51957 | 2/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.46 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.46 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.46 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583238 | 0.86 | AKT1 (1.00) | AKT1AKT2AKT3MMP3MMP9 | |
| SCHEMBL8241403 | 0.85 | AKT1 (0.74) | AKT1AKT2AKT3GSK3BROCK1 | |
| SCHEMBL4583154 | 0.84 | AKT1 (0.72) | AKT1AKT2AKT3DYRK1AGSK3B | |
| SCHEMBL4583609 | 0.82 | AKT1 (1.00) | AKT1AKT2AKT3DYRK1AGSK3B | |
| SCHEMBL4583466 | 0.81 | AKT1 (0.77) | AKT1AKT2AKT3 | |
| SCHEMBL4584796 | 0.79 | AKT1 (0.86) | AKT1AKT2AKT3MMP3MMP9 | |
| SCHEMBL4382843 | 0.79 | AKT1 (0.64) | AKT1DYRK1AGSK3BCDK9ROCK1 | |
| SCHEMBL8240376 | 0.79 | AKT1 (0.65) | AKT1AKT2AKT3DYRK1AGSK3B | |
| SCHEMBL4582789 | 0.78 | AKT1 (0.64) | AKT1DYRK1AGSK3BCDK9CCNT1 | |
| SCHEMBL4583325 | 0.78 | AKT1 (0.83) | AKT1AKT2AKT3MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | claimed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | claimed |