Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 10/20 | 0.58 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.53 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | MELK | Q14680 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4582334 | 0.94 | AKT1 (0.51) | AKT1MAP3K5AKT3AKT2MAP4K4 | |
| SCHEMBL4582358 | 0.87 | MAP3K5 (0.49) | AKT1MAP3K5AKT3AKT2MAP4K4 | |
| SCHEMBL8235518 | 0.82 | AKT1 (0.77) | AKT1AKT3AKT2MAP4K4DYRK1A | |
| SCHEMBL4582789 | 0.79 | AKT1 (0.64) | AKT1MAP4K4DYRK1AMELKCLK4 | |
| SCHEMBL8233616 | 0.78 | AKT1 (0.76) | AKT1MAP3K5AKT3MAP4K4DYRK1A | |
| SCHEMBL4582970 | 0.78 | MAP3K5 (0.39) | AKT1MAP3K5AKT3MAP4K4DYRK1A | |
| SCHEMBL4583788 | 0.77 | AKT1 (0.46) | AKT1MAP3K5AKT3AKT2MAP4K4 | |
| SCHEMBL4584368 | 0.77 | AKT1 (0.59) | AKT1MAP3K5AKT3AKT2MAPK14 | |
| SCHEMBL8240317 | 0.74 | AKT1 (0.45) | AKT1MAP3K5MAPK14ROCK2ROCK1 | |
| SCHEMBL8240614 | 0.74 | AKT1 (1.00) | AKT1AKT3AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |