Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 7/20 | 0.43 |
| ▸ | TTK | P33981 | 4/20 | 0.35 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 8/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 6/20 | 0.32 |
| ▸ | FLT3 | P36888 | 6/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458281 | 0.72 | TYK2 (0.40) | TYK2TTKCDK2CCNE1FLT3 | |
| SCHEMBL455869 | 0.71 | TYK2 (0.41) | TYK2TTKCDK2CCNE1FLT3 | |
| SCHEMBL470186 | 0.70 | TYK2 (0.45) | TYK2TTKCDK2CCNE1FLT3 | |
| SCHEMBL21571914 | 0.61 | TYK2 (1.00) | TYK2TTKSTAT3CDK2CCNE1 | |
| SCHEMBL458935 | 0.56 | TTK (0.41) | TTK | |
| SCHEMBL28629637 | 0.54 | CYP17A1 (0.31) | — | |
| SCHEMBL22421804 | 0.54 | TYK2 (0.77) | TYK2STAT3CDK2CCNE1FLT3 | |
| SCHEMBL19516750 | 0.54 | MEN1 (0.42) | — | |
| SCHEMBL3033387 | 0.53 | PIM1 (0.60) | CDK2FLT3 | |
| SCHEMBL3033386 | 0.53 | PIM1 (0.60) | CDK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614063-B1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER IP GMBH (DE) | 2016-01-13 | — | — | EP | disclosed |
| EP-2614063-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | Bayer Intellectual Property GmbH (DE) | 2013-07-17 | — | — | EP | disclosed |
| WO-2012032031-A1 | SUBSTITUTED IMIDAZOPYRIDAZINES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2012-03-15 | — | — | WO | disclosed |