SCHEMBL4582874

SCHEMBL4582874

Cc1n[nH]c(=O)c(-c2cc(F)c(F)cc2F)c1-c1cccs1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.38
KMT2A Q03164 6/20 0.38
ALDH1A1 P00352 4/20 0.38
HPGD P15428 4/20 0.38
KDM4E B2RXH2 2/20 0.38
HSD17B10 Q99714 2/20 0.38
MAPK1 P28482 1/20 0.38
HTT P42858 1/20 0.38
KCNQ3 O43525 1/20 0.36
KCNQ2 O43526 1/20 0.36
MEN1 O00255 4/20 0.36
GABRA1 P14867 1/20 0.36
GABRG2 P18507 1/20 0.36
GABRB3 P28472 1/20 0.36
GABRA5 P31644 1/20 0.36
GABRA3 P34903 1/20 0.36
GABRA2 P47869 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
DRD1 P21728 1/20 0.35
MAPT P10636 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3617725 0.84 TYMP (0.39) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL4600738 0.81 GABRA1 (0.40) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL4584726 0.79 TYMP (0.45) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL4583123 0.77 DRD1 (0.35) DRD1ALPL
SCHEMBL4583927 0.75 TYMP (0.47) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL2355006 0.74 KCNQ3 (0.42) KMT2AHPGDKDM4EHSD17B10MAPK1
SCHEMBL4608946 0.74 TYMP (0.46) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL2452085 0.72 TYMP (0.46) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL1614981 0.69 KCNQ3 (0.37) TYMPKMT2AALDH1A1HPGDKDM4E
SCHEMBL4582585 0.68 GNRHR (0.37) KMT2AHPGDMEN1NPSR1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1972623-A1 Arylpyridazines as fungicides Bayer CropScience AG (DE) 2008-09-24 EP disclosed