Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.43 |
| ▸ | CDK8 | P49336 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4583354 | 0.79 | HTR6 (0.42) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL4584006 | 0.77 | HTR6 (0.41) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL13332928 | 0.74 | HTR6 (0.50) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL29605131 | 0.73 | HTR6 (0.46) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL1044724 | 0.73 | CDK2 (0.47) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL2529105 | 0.73 | HTR6 (0.51) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL8233323 | 0.72 | HTR6 (0.39) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL29606686 | 0.71 | HTR6 (0.51) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL17165465 | 0.71 | CCNC (0.52) | CCNCCDK8HTR6CCNE1CDK2 | |
| SCHEMBL1049986 | 0.71 | CYP2C19 (0.49) | CCNCCDK8HTR6CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |