Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 10/20 | 0.41 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.39 |
| ▸ | CDK2 | P24941 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8233323 | 0.89 | HTR6 (0.39) | HTR6CCNCCDK8CCNE1CDK2 | |
| SCHEMBL4583354 | 0.85 | HTR6 (0.42) | HTR6CCNCCDK8CCNE1CDK2 | |
| SCHEMBL4584452 | 0.82 | HTR6 (0.44) | HTR6CCNCCDK8CCNE1CDK2 | |
| SCHEMBL8241863 | 0.80 | ELANE (0.38) | HTR6CCNCCDK8CCNE1CDK2 | |
| SCHEMBL4583381 | 0.79 | PTPRB (0.41) | HTR6CDK2 | |
| SCHEMBL4582983 | 0.77 | CCNC (0.43) | HTR6CCNCCDK8CCNE1CDK2 | |
| SCHEMBL4476225 | 0.76 | L3MBTL1 (0.45) | PTGDR2L3MBTL1 | |
| SCHEMBL4591926 | 0.75 | AKT1 (0.43) | HTR6CYP2C19PIK3C3L3MBTL1 | |
| SCHEMBL8944259 | 0.72 | L3MBTL1 (0.67) | HTR6CCNCCDK8PTGDR2CYP2C19 | |
| SCHEMBL17165375 | 0.72 | HTR6 (0.45) | HTR6CCNCCDK8CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968568-A2 | INHIBITORS OF Akt ACTIVITY | SmithKline Beecham Corporation (US) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007076423-A2 | INHIBITORS OF Akt ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |